Protein Info for CSW01_16865 in Vibrio cholerae E7946 ATCC 55056

Annotation: ClC family H(+)/Cl(-) exchange transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 468 transmembrane" amino acids 31 to 51 (21 residues), see Phobius details amino acids 73 to 95 (23 residues), see Phobius details amino acids 123 to 143 (21 residues), see Phobius details amino acids 175 to 199 (25 residues), see Phobius details amino acids 211 to 230 (20 residues), see Phobius details amino acids 250 to 270 (21 residues), see Phobius details amino acids 289 to 307 (19 residues), see Phobius details amino acids 326 to 346 (21 residues), see Phobius details amino acids 354 to 375 (22 residues), see Phobius details amino acids 387 to 411 (25 residues), see Phobius details amino acids 418 to 438 (21 residues), see Phobius details PF00654: Voltage_CLC" amino acids 88 to 434 (347 residues), 336.8 bits, see alignment E=7.7e-105

Best Hits

Swiss-Prot: 100% identical to CLCA_VIBCM: H(+)/Cl(-) exchange transporter ClcA (clcA) from Vibrio cholerae serotype O1 (strain M66-2)

KEGG orthology group: K03281, chloride channel protein, CIC family (inferred from 100% identity to vco:VC0395_0459)

MetaCyc: 60% identical to chloride:H+ antiporter ClcA (Escherichia coli K-12 substr. MG1655)
RXN0-2501

Predicted SEED Role

"H(+)/Cl(-) exchange transporter ClcA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (468 amino acids)

>CSW01_16865 ClC family H(+)/Cl(-) exchange transporter (Vibrio cholerae E7946 ATCC 55056)
MSTRETFKISLLAKMPKDVINQFLSKDKTPFSVLFLSLLVGILAGLVGTYFEQAVHLVSE
TRTDWLKSEIGSFLPLWLAAFLISAFLAFIGYFLVHRFAPEAAGSGIPEIEGAMDGMRPV
RWWRVLPVKFFGGMGALGSGMVLGREGPTVQMGGAVGRMISDIFRVKNEDTRHSLLAAGA
AGGLAAAFNAPLAGIMFVIEEMRPQFRYTLISVRAVIISAVAANIVFRVINGQDAVITMP
QYDAPELSTLGLFLLLGALFGVFGVLFNYLITLAQDLFVKFHRNDRKRYLLTGSMIGGCF
GLLLLYVPELTGGGISLIPTITNGGYGAGILLLLFVGRIFTTLLCFGSGAPGGIFAPMLA
LGTLFGYAFGLIAKMWFPELNIEPGMFAIAGMGALFAATVRAPITGILLVIEMTNNYHLI
LPLIITSLGAVIFAQLLGGQPIYSQLLHRTLKNQKLQQQDLPPQSPNS