Protein Info for CSW01_16850 in Vibrio cholerae E7946 ATCC 55056

Annotation: hybrid sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 686 transmembrane" amino acids 20 to 36 (17 residues), see Phobius details amino acids 48 to 65 (18 residues), see Phobius details amino acids 77 to 96 (20 residues), see Phobius details amino acids 102 to 119 (18 residues), see Phobius details amino acids 126 to 143 (18 residues), see Phobius details amino acids 155 to 172 (18 residues), see Phobius details PF02518: HATPase_c" amino acids 312 to 414 (103 residues), 72.4 bits, see alignment E=4.2e-24 PF00072: Response_reg" amino acids 570 to 682 (113 residues), 93 bits, see alignment E=1.4e-30

Best Hits

Swiss-Prot: 100% identical to CQSS_VIBCH: CAI-1 autoinducer sensor kinase/phosphatase CqsS (cqsS) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K10916, two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC: 2.7.13.3 3.1.3.-] (inferred from 100% identity to vcm:VCM66_A0481)

Predicted SEED Role

"Sensor histidine kinase CqsS"

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 3.1.3.-

Use Curated BLAST to search for 2.7.13.3 or 3.1.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (686 amino acids)

>CSW01_16850 hybrid sensor histidine kinase/response regulator (Vibrio cholerae E7946 ATCC 55056)
MIVSMDVIKRVYQYAEPNLSLVGWMGMLGFPAYYFIWEYWFPQSYENLGLRCAAAVLFGG
LVFRDSMPKKWQRYMPGYFLFTIGFCLPFFFAFMMLMNDWSTIWAMSFMASIFLHILLVH
DTRVMALQALFSVLVAYLAVYGLTDFHPTTLIEWQYIPIFLFTYVFGNLCFFRNQISHET
KVSIAKTFGAGIAHEMRNPLSALKTSIDVVRTMIPKPQTAAHTDYSLDAQELDLLHQILN
EADDVIYSGNNAIDLLLTSIDENRVSPASFKKHSVVDVIEKAVKTFPYKNAADQHSVELE
VHQPFDFFGSDTLLTYALFNLLKNAFYYQKEHFSVCISIEQTSEHNLIRVRDNGVGIAPE
MLEDIFRDFYTFGKNGSYGLGLPFCRKVMSAFGGTIRCASQQGQWTEFVLSFPRYDSDTV
NEIKTELLKTKSLIYIGSNQAIVRELNQLAVEDEFGFTAISAQQAVRRQDYEFEFDLILL
DLDDATAQGELLPKLEGTLSFAEGCIGYVYDPGKTYAVNINRYLRIQPISIHSILRKPRK
IIERLLFEQESLSMNRNVIPLQKSRHERRILVVDDNQSIRTFTAILLEQQGYEVVQANDG
SEVLKHMESQNIDLVLMDIEMPNVGGLEATRLIRNSEHEYKNIPIIGYTGDNSPKTLALV
QTSGMNDFIVKPADRDVLLNKVAAWV