Protein Info for CSW01_15720 in Vibrio cholerae E7946 ATCC 55056

Annotation: LD-carboxypeptidase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 334 PF02016: Peptidase_S66" amino acids 13 to 132 (120 residues), 122.8 bits, see alignment E=9.4e-40 PF17676: Peptidase_S66C" amino acids 202 to 316 (115 residues), 86.2 bits, see alignment E=2.8e-28

Best Hits

Swiss-Prot: 100% identical to Y3137_VIBCH: Putative carboxypeptidase VC_A0337 (VC_A0337) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: None (inferred from 100% identity to vch:VCA0439)

Predicted SEED Role

"Muramoyltetrapeptide carboxypeptidase (EC 3.4.17.13)" (EC 3.4.17.13)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 3.4.17.13

Use Curated BLAST to search for 3.4.17.13

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (334 amino acids)

>CSW01_15720 LD-carboxypeptidase (Vibrio cholerae E7946 ATCC 55056)
MLYAKALSIGDEIGFFSPSSPATAFAPNRFQRAKAYLKAQGFELVEGSLTGKSDYYRSGS
IRERAEELNQLIRDPNVRCIMPTIGGNNSNSLLPYIDYEALRNDPKIIIGYSDVTALLLG
IYAQTGLITFYGPALVASFGEYPPLVDETFHSFIDLLCSETNQYQYTMPSSWTDIKHDWE
TQHSAKPVYPNEWQFIGKGKVTGRIIGGNLNTMAGIWGSRYMPEIKVGDILLIEDSLKGI
ENVERSFAHLAACGVFERVSAIILGKHELFDNKGTGRTPLDVLIEVLADKNVPIFYGFDS
CHTHPMLVTPLGVRGTIDFDNHTFKLEDRWVKAK