Protein Info for CSW01_15510 in Vibrio cholerae E7946 ATCC 55056

Annotation: deoxyguanosinetriphosphate triphosphohydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 402 TIGR01353: putative dGTPase" amino acids 35 to 392 (358 residues), 371.5 bits, see alignment E=3.7e-115 PF01966: HD" amino acids 72 to 211 (140 residues), 35.6 bits, see alignment E=1e-12 PF13286: HD_assoc" amino acids 307 to 389 (83 residues), 55.4 bits, see alignment E=7.5e-19

Best Hits

Swiss-Prot: 100% identical to DGT1B_VIBCH: Deoxyguanosinetriphosphate triphosphohydrolase-like protein 2 (VC_A0308) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: None (inferred from 100% identity to vcj:VCD_000970)

Predicted SEED Role

"Deoxyguanosinetriphosphate triphosphohydrolase (EC 3.1.5.1)" in subsystem Purine conversions (EC 3.1.5.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.1.5.1

Use Curated BLAST to search for 3.1.5.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (402 amino acids)

>CSW01_15510 deoxyguanosinetriphosphate triphosphohydrolase (Vibrio cholerae E7946 ATCC 55056)
MYDSEVIEYAKEQENIISKLEYRVYKHDDGRSVNRQDLMRDYARVLYSSSFRRLQGKMQL
LGVDASKFNRNRLTHSLEVAQIARSIAYDLELNHTVVAETASLAHDIGNPPFGHYGEVVL
NDLSLACGGYEGNAQAFRILRTLEKKHYAYPGLNLNVRTLMAITKYFFNKHQNNKKFLYD
ADYEFLKTELDSKGVTVTKSIDAEIMDLADEIAYAAHDLEDALSFGMISLGEIVHEFSIS
DKFKDAYPTMTDIAKEAQNVAMKASRSGTSEEYAIVLKKELTSMIVNILCSDIGLVDGCL
GYKRHAKLAEGLKKLLFKAILRKKDIQLYERRGEQIIRGLFEVYSDEKYNKDNMLLPPEL
RAINDCKTRLVTDYISGMMDSYAAQEYEKYFGKGSADKLYFK