Protein Info for CSW01_15095 in Vibrio cholerae E7946 ATCC 55056

Annotation: protease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 918 signal peptide" amino acids 1 to 24 (24 residues), see Phobius details PF05547: Peptidase_M6" amino acids 105 to 393 (289 residues), 505.2 bits, see alignment E=2e-155 TIGR03296: M6 family metalloprotease domain" amino acids 121 to 442 (322 residues), 285.5 bits, see alignment E=3.4e-89 PF20773: InhA-like_MAM" amino acids 406 to 588 (183 residues), 266.7 bits, see alignment E=3.5e-83 PF20774: InhA-like_VEG" amino acids 589 to 747 (159 residues), 249.2 bits, see alignment E=7.2e-78 PF18911: PKD_4" amino acids 769 to 835 (67 residues), 60.1 bits, see alignment 6.2e-20 amino acids 858 to 916 (59 residues), 27.4 bits, see alignment 1e-09 PF00801: PKD" amino acids 778 to 828 (51 residues), 46.1 bits, see alignment 1.4e-15 amino acids 844 to 913 (70 residues), 55.2 bits, see alignment 2.1e-18

Best Hits

Swiss-Prot: 100% identical to PRTV_VIBCH: Pre-pro-metalloprotease PrtV (prtV) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K09607, immune inhibitor A [EC: 3.4.24.-] (inferred from 100% identity to vcj:VCD_000030)

Predicted SEED Role

"Metalloprotease, putative zinc-binding domain" in subsystem Cytolysin and Lipase operon in Vibrio

Isozymes

Compare fitness of predicted isozymes for: 3.4.24.-

Use Curated BLAST to search for 3.4.24.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (918 amino acids)

>CSW01_15095 protease (Vibrio cholerae E7946 ATCC 55056)
MKTIKKTLLAAAIASFFSSGLYAQTPIDLGVVNEDKLIEMLVRTGQIPADASDVDKRIAL
ERYLEEKIRSGFKGDAQFGKKALEQRAKILKVIDKQKGPHKARVFALDVGQKRTDKVLAL
LIDFPDLPWDDNRLTKEHTEMLYDRYEPSHYQDLLFSDKGYTGPNGENFISMRQYYESES
GNSYSVSGQAAGWYRASKNAAYYGGNSPGTNNDMNARELVREALDQLARDPNINLADYDI
EDRYDYNGNGNFREPDGVIDHLMIFHASVGEEAGGGVLGADAIWSHRFNLGRYHVLEGTK
SNVPGRFNGQFAAFDYTIQPIDAAAGVCAHEYGHDLGLPDEYDTQYTGTGEPVSYWSIMS
SGSWAGKIGGTQPTAFSSWAKQFLQNSIGGRWINHEQLSINELEAKPRVVTLFQTTDNSR
PNMVKVTLPMKRVEGIKPAEGEFSFYSNRGDDLKNRMSRPLTIPAGSQATLRFKAWFQIE
KDYDYARVLINGKPIAGNITTMDDPFKSGLVPAISGQSDGWVDAQFDLSAWAGQTVELAF
DYLTDGGLAMEGLYVDDLRLEVDGNQTLIDNAEGTSSFAFQGFTKNGGFHEANHYYLLQW
RSHNDVDQGLANLKRFGQLMSFEPGLLVWYVDESYADNWVGKHPGEGWLGVVDADQNALV
WSKTGEVAQTRFQVRDATFSLFDQAPLKLVTADGNTLEDMNLTANASFSDDQDYSSPQAP
DSGRKVMPFGLKIDLLSQSKENEYGVVRLSKVTTENIAPVARFELKVEGLSVMSQNTSSD
SDGNIVSYLWDFGNGQTSTEAAPTWSYTKAGSYSVTLTVTDDKGDSDTHQQTIKVDTPNA
LPQASANYIHLGRWVTMWSTSTDSDGRIVDTEWTLPNGKIKRGRMFTAIFPSYGHHDVQL
KVMDDRGAVTTITIKVKL