Protein Info for CSW01_15070 in Vibrio cholerae E7946 ATCC 55056

Annotation: thermolabile hemolysin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 418 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details PF00657: Lipase_GDSL" amino acids 149 to 408 (260 residues), 101.1 bits, see alignment E=4.9e-33

Best Hits

Swiss-Prot: 65% identical to HLT_VIBPA: Thermolabile hemolysin (VPA0226) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K11018, thermolabile hemolysin (inferred from 100% identity to vco:VC0395_1011)

Predicted SEED Role

"Thermolabile hemolysin precursor"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (418 amino acids)

>CSW01_15070 thermolabile hemolysin (Vibrio cholerae E7946 ATCC 55056)
MKKRLSILIAGLASLSVNAATEPWASPEAEVLSRAQIQQVQGKQTYTYVRCWYRPAATHD
DPYTTWEWAKNADGSYYTIQGYWWSSIRQKNMFYTTVQPETLLERCEETLGVNHDFADIT
YFAADHRFSYNHTIWSNDPEVQSNRISKVIAFGDSLSDTGNIFNASQWRFPNPDSWFLGH
FSNGFVWTEYLAQGLNVPLYNWAVGGAAGRNQYVALTGVYEQVSSYLSYMRLAKNYQPEN
SLFTLEFGLNDFMNYNRSLADVKADYSSALIRLIDAGAKNLVLMTLPDATRAPQFQYATQ
EQIDTVRSKIIGMNAFIREQARYYQMQGIRIVLFDAYTLFDSITTQPEQHGFANANSPCL
DIRRNSAADYLLSHSLSAECAKQGSDRFVFWEVTHPTTAIHHYLAEQILATEMAQFPL