Protein Info for CSW01_14975 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA cytosine methyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00145: DNA_methylase
  • amino acids 20 to 376 (357 residues), 162.7 bits, E=7.6e-52
• TIGR00675: DNA (cytosine-5-)-methyltransferase
  • amino acids 20 to 374 (355 residues), 152.8 bits, E=9.4e-49

Best Hits

KEGG orthology group: K00558, DNA (cytosine-5-)-methyltransferase [EC: 2.1.1.37] (inferred from 100% identity to vcm:VCM66_A0194)

Predicted SEED Role

"DNA-cytosine methyltransferase (EC 2.1.1.37)" (EC 2.1.1.37)

KEGG Metabolic Maps

• Methionine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.1.1.37

Protein Sequence (383 amino acids)

>CSW01_14975 DNA cytosine methyltransferase (Vibrio cholerae E7946 ATCC 55056)
MITLTVWAFNLFSPSKPIIFSFFAGSGFLDLGFETSGFDVRFVNEFHKPFLDAYKYSREH
MGLPKPKYGHYLGSIDDFVTGEKKQLLYDLVQEAKSEALTGFIGGPPCPDFSVAGKNKGS
DGENGILTRVYIDAIVQNQPDFFLFENVKGLWKTGKHRAFYDAMKAHLEDAGYVLTDRLT
NSIEFGVPQDRDRILMFGIHRKHVGDKLTSIELARDFDWEREVKFDKTKVLDKSIWPELA
TYKENSIRKLPKHLDNYRELTVEHWFQKNDVNQHLNAKHHFRPYSDKFKTIQEGDDKKKS
FKRLHRYRFSPTAAYGNNEVHLHPYKPRRLSAAEALAIQSLPKEFHLPPTMTLSDMFKTI
GNGVPFLASKCIAQTIHNYLESL