Protein Info for CSW01_14970 in Vibrio cholerae E7946 ATCC 55056

Annotation: guanosine monophosphate reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 347 TIGR01305: guanosine monophosphate reductase" amino acids 2 to 344 (343 residues), 608.4 bits, see alignment E=1.7e-187 PF00478: IMPDH" amino acids 9 to 338 (330 residues), 264.3 bits, see alignment E=7.7e-83

Best Hits

Swiss-Prot: 100% identical to GUAC_VIBC3: GMP reductase (guaC) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K00364, GMP reductase [EC: 1.7.1.7] (inferred from 100% identity to vcj:VCD_000053)

MetaCyc: 73% identical to GMP reductase (Escherichia coli K-12 substr. MG1655)
GMP reductase. [EC: 1.7.1.7]

Predicted SEED Role

"GMP reductase (EC 1.7.1.7)" in subsystem Purine conversions (EC 1.7.1.7)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.7.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (347 amino acids)

>CSW01_14970 guanosine monophosphate reductase (Vibrio cholerae E7946 ATCC 55056)
MRIEQELKLGFKDVLFRPKRSTLKSRSQVNLTREFTFKHSGRQWSGVPVIAANMDSVGSF
AMAKALAEHGVMTAVHKHYTVADWAEFVKSADKATLNNVMVSTGTSEADFQKTKDVMALS
DELIFICIDIANGYSEHLVEYVQRVRAAFPDKVISAGNVVTGDMVEELILAGADIVKVGI
GPGSVCTTRVKTGVGYPQLSAIIECADAAHGLGGRIIGDGGCTCPGDVAKAFGGGADFVM
LGGMLAGHEEAGGELIVKDGETFMKFYGMSSKSAMDKHSGGVAGYRAAEGKTVLLPYRGS
VHGTIQDILGGVRSTCTYVGAAELRELTKRTTFIRVQEQENNVYGRE