Protein Info for CSW01_14775 in Vibrio cholerae E7946 ATCC 55056

Annotation: Na+/H+ antiporter subunit D

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 498 transmembrane" amino acids 6 to 24 (19 residues), see Phobius details amino acids 33 to 54 (22 residues), see Phobius details amino acids 69 to 98 (30 residues), see Phobius details amino acids 110 to 127 (18 residues), see Phobius details amino acids 133 to 152 (20 residues), see Phobius details amino acids 164 to 184 (21 residues), see Phobius details amino acids 207 to 229 (23 residues), see Phobius details amino acids 239 to 262 (24 residues), see Phobius details amino acids 271 to 291 (21 residues), see Phobius details amino acids 300 to 321 (22 residues), see Phobius details amino acids 326 to 347 (22 residues), see Phobius details amino acids 367 to 386 (20 residues), see Phobius details amino acids 404 to 426 (23 residues), see Phobius details amino acids 448 to 469 (22 residues), see Phobius details PF10125: NADHdeh_related" amino acids 121 to 203 (83 residues), 29.1 bits, see alignment E=6.6e-11 PF00361: Proton_antipo_M" amino acids 129 to 417 (289 residues), 201.5 bits, see alignment E=1.8e-63

Best Hits

KEGG orthology group: K05568, multicomponent Na+:H+ antiporter subunit D (inferred from 100% identity to vcj:VCD_000092)

Predicted SEED Role

"Na(+) H(+) antiporter subunit D" in subsystem Sodium Hydrogen Antiporter

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (498 amino acids)

>CSW01_14775 Na+/H+ antiporter subunit D (Vibrio cholerae E7946 ATCC 55056)
MTAIGLTLPVVISLLTAVAIFLAGRNRWLTNGLSVICSVINLFTGALLTITIYTHGPASI
AFGQWPAPFGIVFVADLLSVGMVMVTAIIGLVSVIYAIADLSAKPSYARYHALLHVLLAG
VYGAFLTGDIFNLYVWFEVMLIASFGLMVLDANQQQIDGAIKYVLLNLISTLVFLLSIGL
LYGATGTLNLADLHDKAQSLAPEMKTMLAGLLLFAFSIKAALFPLFAWLPASYHTLPSAI
VALFAALLTKVGVYALLRVFTLVFPLDGSGWQPVLLGIAALTMLTGVLGAASQYDIKKIL
SFHIISQIGYMIMGLAIYTPLAITGAIFYVIHHILVKGNLFLIGGLIGRKYGTTQLTQLG
GVYRAMPWLTFGFLLAAFSLAGFPPLSGFWGKFLVIKASLAAELYWLAAIALLVGLLTIF
SMTKIWNEVFWKDAPAALQQETLARSTLGLYALPILVLTLFSLVIGLAAQPFYQFATLAA
EQLLTPTAYIHAVLGGSK