Protein Info for CSW01_14670 in Vibrio cholerae E7946 ATCC 55056

Annotation: transcriptional repressor PurR

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 334 PF00356: LacI" amino acids 3 to 48 (46 residues), 71.4 bits, see alignment 8.7e-24 PF00532: Peripla_BP_1" amino acids 59 to 308 (250 residues), 109.6 bits, see alignment E=4e-35 PF13407: Peripla_BP_4" amino acids 62 to 308 (247 residues), 72.1 bits, see alignment E=1.2e-23 PF13377: Peripla_BP_3" amino acids 169 to 330 (162 residues), 145.2 bits, see alignment E=4.2e-46

Best Hits

Swiss-Prot: 56% identical to RBSR_SHIFL: Ribose operon repressor (rbsR) from Shigella flexneri

KEGG orthology group: K02529, LacI family transcriptional regulator (inferred from 100% identity to vch:VCA0132)

MetaCyc: 48% identical to DNA-binding transcriptional repressor PurR (Escherichia coli K-12 substr. MG1655)

Predicted SEED Role

"Ribose operon repressor" in subsystem D-ribose utilization

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (334 amino acids)

>CSW01_14670 transcriptional repressor PurR (Vibrio cholerae E7946 ATCC 55056)
MATMKDIARLAGVSTSTVSHVINKSRFVSDEIAERVNNAAQQLNYAPSALARSLKMNRTK
TIGMLVTTSTNPFFGEVVKGVERSCYHQGYNLILCNTEGDNQRMKASINTLLQKRVDGLL
LMCSTLEGERLDVFDRYPDIPIVVMDWGPILFASDKIQDNSLQGGYMAAKHLIECGHKEI
GCITGPLIRHQAQMRYEGYKRALAEAGIAINPDWIVESDFECEGGYQAFEKLYQRGKLPS
ALFVSNDMMAMGVIQAASQRGLRVPDDLSLIGYDDVHIAKFMTPALTTIHQPKYRLGKAA
VDTLLYRLENPDTTAQVVQLEPTLVVRNSVRKLG