Protein Info for CSW01_14590 in Vibrio cholerae E7946 ATCC 55056

Annotation: type IV secretion protein DotU

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 257 transmembrane" amino acids 149 to 164 (16 residues), see Phobius details amino acids 219 to 241 (23 residues), see Phobius details TIGR03349: type IV/VI secretion system protein, DotU family" amino acids 37 to 246 (210 residues), 235.7 bits, see alignment E=2.5e-74 PF09850: DotU" amino acids 39 to 240 (202 residues), 219.5 bits, see alignment E=1.9e-69

Best Hits

KEGG orthology group: K11892, type VI secretion system protein ImpK (inferred from 100% identity to vch:VCA0115)

Predicted SEED Role

"Outer membrane protein ImpK/VasF, OmpA/MotB domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (257 amino acids)

>CSW01_14590 type IV secretion protein DotU (Vibrio cholerae E7946 ATCC 55056)
MSQSKKETPLASLLFDDVEKINHDQDYWFQLRGDNPNVLIDAATPLFGLSLRVRTLTECD
NIEQIYRQTIEEIKAIEIELTEQGYEHAILMAYRYILCAFLDESVMGTEWGASSLWAEHS
MLSRFHNETWGGEKVFTILSRLEGEPHRYQALLAFIYHCLILGFEGKYRVMEGGQAEREK
VISRLHQLLSSLEESEPQDLTRPTDHVVRAKYTLSRQMPVWSVFAGFIVLWVGLFLGYSY
VLHSKSSDVLNQLNQIL