Protein Info for CSW01_14030 in Vibrio cholerae E7946 ATCC 55056

Annotation: ATP synthase subunit A

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 270 transmembrane" amino acids 42 to 61 (20 residues), see Phobius details amino acids 97 to 116 (20 residues), see Phobius details amino acids 144 to 163 (20 residues), see Phobius details amino acids 183 to 202 (20 residues), see Phobius details amino acids 208 to 230 (23 residues), see Phobius details amino acids 238 to 262 (25 residues), see Phobius details TIGR01131: ATP synthase F0, A subunit" amino acids 35 to 263 (229 residues), 151.1 bits, see alignment E=2.3e-48 PF00119: ATP-synt_A" amino acids 44 to 262 (219 residues), 197.1 bits, see alignment E=1.9e-62

Best Hits

Swiss-Prot: 100% identical to ATP6_VIBC3: ATP synthase subunit a (atpB) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K02108, F-type H+-transporting ATPase subunit a [EC: 3.6.3.14] (inferred from 100% identity to vcj:VCD_001466)

MetaCyc: 66% identical to ATP synthase Fo complex subunit a (Escherichia coli K-12 substr. MG1655)
ATPSYN-RXN [EC: 7.1.2.2]; RXN0-7041 [EC: 7.1.2.2]

Predicted SEED Role

"ATP synthase F0 sector subunit a"

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.6.3.14

Use Curated BLAST to search for 3.6.3.14 or 7.1.2.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (270 amino acids)

>CSW01_14030 ATP synthase subunit A (Vibrio cholerae E7946 ATCC 55056)
MAAPGEALTPSSYITHHLTNLSTYKLGLVAEESSFWNVHIDSLFFSVLTGLIFLGVFRAV
ARKATAGVPGKLQCAVEMVVEFVDKNVKDTFHGRNPLIAPLALTIFCWVFLMNLMDLVPI
DFLPYPAQHWLGIPYLKVVPSADVNITMAMALGVFALMIYYSIKVKGLGGFAKELALHPF
NHWIMIPFNLLIEVVSLLAKPLSLGMRLFGNMFAGEVVFILCAAMLPWYLQWMGSLPWAI
FHILVILIQSFVFMMLTIVYMSMAHEDNDH