Protein Info for CSW01_13790 in Vibrio cholerae E7946 ATCC 55056

Annotation: type II secretion system protein GspD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 674 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details TIGR02517: type II secretion system protein D" amino acids 30 to 620 (591 residues), 524.6 bits, see alignment E=1.7e-161 PF21305: type_II_gspD_N0" amino acids 30 to 99 (70 residues), 88.9 bits, see alignment E=2.4e-29 PF03958: Secretin_N" amino acids 126 to 188 (63 residues), 47.4 bits, see alignment E=2.8e-16 amino acids 192 to 259 (68 residues), 61.6 bits, see alignment E=1e-20 amino acids 267 to 343 (77 residues), 55.4 bits, see alignment E=8.5e-19 PF00263: Secretin" amino acids 450 to 611 (162 residues), 171.1 bits, see alignment E=2.4e-54

Best Hits

Swiss-Prot: 100% identical to GSPD_VIBCH: Secretin GspD (epsD) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02453, general secretion pathway protein D (inferred from 100% identity to vcj:VCD_001634)

Predicted SEED Role

"General secretion pathway protein D"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (674 amino acids)

>CSW01_13790 type II secretion system protein GspD (Vibrio cholerae E7946 ATCC 55056)
MKYWLKKSSWLLAGSLLSTPLAMANEFSASFKGTDIQEFINIVGRNLEKTIIVDPSVRGK
VDVRSFDTLNEEQYYSFFLSVLEVYGFAVVEMDNGVLKVIKSKDAKTSAIPVLSGEERAN
GDEVITQVVAVKNVSVRELSPLLRQLIDNAGAGNVVHYDPANIILITGRAAVVNRLAEII
RRVDQAGDKEIEVVELNNASAAEMVRIVEALNKTTDAQNTPEFLKPKFVADERTNSILIS
GDPKVRERLKRLIKQLDVEMAAKGNNRVVYLKYAKAEDLVEVLKGVSENLQAEKGTGQPT
TSKRNEVMIAAHADTNSLVLTAPQDIMNAMLEVIGQLDIRRAQVLIEALIVEMAEGDGIN
LGVQWGSLESGSVIQYGNTGASIGNVMIGLEEAKDTTQTKAVYDTNNNFLRNETTTTKGD
YTKLASALSSIQGAAVSIAMGDWTALINAVSNDSSSNILSSPSITVMDNGEASFIVGEEV
PVITGSTAGSNNDNPFQTVDRKEVGIKLKVVPQINEGNSVQLNIEQEVSNVLGANGAVDV
RFAKRQLNTSVMVQDGQMLVLGGLIDERALESESKVPLLGDIPLLGQLFRSTSSQVEKKN
LMVFIKPTIIRDGVTADGITQRKYNYIRAEQLFRAEKGLRLLDDASVPVLPKFGDDRRHS
PEIQAFIEQMEAKQ