Protein Info for CSW01_13635 in Vibrio cholerae E7946 ATCC 55056

Annotation: thiol:disulfide interchange protein DsbD

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 signal peptide" amino acids 1 to 22 (22 residues), see Phobius details transmembrane" amino acids 196 to 219 (24 residues), see Phobius details amino acids 237 to 262 (26 residues), see Phobius details amino acids 274 to 296 (23 residues), see Phobius details amino acids 318 to 346 (29 residues), see Phobius details amino acids 358 to 381 (24 residues), see Phobius details amino acids 394 to 412 (19 residues), see Phobius details amino acids 418 to 435 (18 residues), see Phobius details amino acids 447 to 469 (23 residues), see Phobius details PF11412: DsbD_N" amino acids 40 to 152 (113 residues), 105.8 bits, see alignment E=4.4e-34 PF02683: DsbD_TM" amino acids 196 to 412 (217 residues), 284.2 bits, see alignment E=1.7e-88 PF13386: DsbD_2" amino acids 211 to 395 (185 residues), 36.5 bits, see alignment E=1.5e-12 PF13899: Thioredoxin_7" amino acids 488 to 552 (65 residues), 54 bits, see alignment E=4.6e-18 PF13098: Thioredoxin_2" amino acids 499 to 593 (95 residues), 35.1 bits, see alignment E=4.2e-12 PF00085: Thioredoxin" amino acids 502 to 574 (73 residues), 33.1 bits, see alignment E=1.4e-11

Best Hits

Swiss-Prot: 100% identical to DSBD_VIBCH: Thiol:disulfide interchange protein DsbD (dsbD) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K04084, thiol:disulfide interchange protein DsbD [EC: 1.8.1.8] (inferred from 100% identity to vcm:VCM66_2621)

Predicted SEED Role

"Cytochrome c-type biogenesis protein DsbD, protein-disulfide reductase (EC 1.8.1.8)" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange (EC 1.8.1.8)

Isozymes

Compare fitness of predicted isozymes for: 1.8.1.8

Use Curated BLAST to search for 1.8.1.8

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (600 amino acids)

>CSW01_13635 thiol:disulfide interchange protein DsbD (Vibrio cholerae E7946 ATCC 55056)
MRTLILCFSLLFALLTQPAWAIFGNNAGNNTGTASFAPTQNRFVPVDEAFPFNAFQQGST
LFIDWQVKEGYYLYQDRISISGENLEIGEYSLTEGEPYHDEFFGDVKIYTTPLSVPLPLV
AYQSGAKVIVQYQGCAKAGFCYPPETRVIDITPFNAESNRVIEPKTNTSTQTTLPQTDNA
PTSAQDSLANKLAQNWWTPLLFLALGVGLAFTPCVLPMYPILTSIVLGGAQLTQRRALLL
SVIYVQGMALTYTLLGLVVASAGLQFQAALQHPYVLMGLSVLFVALALSMFGLYSLQLPS
GVQTWLNSLSNAQQGGSLPGVFAMGAISGLVCSPCTTAPLSGALLYVAQSGDLLTGAVAL
YALAIGMGIPLILVAVFGNKLLPKAGNWMERVKTLFGFVLLAAPIFLLERIVPEFWSSVL
WSALGLAAFGWLYHVKNSLPFGGWKQSLIGIVAILGLLASAQPLLNHWLAPTQTAQQVKQ
IQFTRIANLSELQSALAEAKAQGKSVMLDFYADWCVACKEFEKYTFHAKQVENKLSGFVL
LQADVTKNQPQDIELLKALNVLGLPTIEFWNAQGEPVPNARITGFMAEQPFLDHLTQQGL