Protein Info for CSW01_13290 in Vibrio cholerae E7946 ATCC 55056

Annotation: DNA adenine methylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 277 TIGR00571: DNA adenine methylase" amino acids 5 to 268 (264 residues), 321.6 bits, see alignment E=2.4e-100 PF02086: MethyltransfD12" amino acids 10 to 252 (243 residues), 251.2 bits, see alignment E=6.7e-79

Best Hits

Swiss-Prot: 100% identical to DMA_VIBC3: DNA adenine methylase (dam) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K06223, DNA adenine methylase [EC: 2.1.1.72] (inferred from 100% identity to vcm:VCM66_2546)

MetaCyc: 64% identical to DNA adenine methyltransferase (Escherichia coli K-12 substr. MG1655)
Site-specific DNA-methyltransferase (adenine-specific). [EC: 2.1.1.72]

Predicted SEED Role

"Methyl-directed repair DNA adenine methylase (EC 2.1.1.72)" in subsystem DNA repair, bacterial (EC 2.1.1.72)

Isozymes

Compare fitness of predicted isozymes for: 2.1.1.72

Use Curated BLAST to search for 2.1.1.72

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (277 amino acids)

>CSW01_13290 DNA adenine methylase (Vibrio cholerae E7946 ATCC 55056)
MKKQRAFLKWAGGKYSLVEDIQRHLPEARELVEPFVGAGSVFLNTDFERYLLADINPDLI
NFYNLLKTEPQAYIHEAKRWFVPENNRKEVYLDIRKQFNQSDDAMFRSLAFLYMNRFGFN
GLCRYNKKGGFNVPFGSYKKPYFPEQELEFFAEKAQRATFICASYGETFARAQSDSVIYC
DPPYAPLSTTANFTSYAGNGFTLDDQAALADIAEKTAKERGISVLISNHDTTHTRRLYRG
AQLNVVKANRTISRNGAGRNKVDELLALFTPHLSSQA