Protein Info for CSW01_12890 in Vibrio cholerae E7946 ATCC 55056

Annotation: inorganic pyrophosphatase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00719: Pyrophosphatase
  • amino acids 18 to 173 (156 residues), 194.9 bits, E=3.5e-62

Best Hits

Swiss-Prot: 100% identical to IPYR_VIBCH: Inorganic pyrophosphatase (ppa) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K01507, inorganic pyrophosphatase [EC: 3.6.1.1] (inferred from 100% identity to vco:VC0395_A2123)

MetaCyc: 84% identical to inorganic pyrophosphatase (Escherichia coli K-12 substr. MG1655)
Triphosphatase. [EC: 3.6.1.25]; Inorganic diphosphatase. [EC: 3.6.1.25, 3.6.1.1]

Predicted SEED Role

"Inorganic pyrophosphatase (EC 3.6.1.1)" in subsystem Phosphate metabolism (EC 3.6.1.1)

MetaCyc Pathways

• glyphosate degradation III (2/7 steps found)
• (aminomethyl)phosphonate degradation (2/8 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.1

Use Curated BLAST to search for 3.6.1.1 or 3.6.1.25

Protein Sequence (176 amino acids)

>CSW01_12890 inorganic pyrophosphatase (Vibrio cholerae E7946 ATCC 55056)
MSLNNVPAGKSLPDDIYVVIEIPANADPIKYEVDKESGAVFVDRFMSAPMFYPCNYGYVN
HTLSLDGDPVDVLVPTPYPLIPGSVIRCRPVGVLKMTDESGEDAKVVAVPHTKISKEYDH
IQDVNDLPALLKAQITHFFERYKELESGKWVKVDGWEDAASARAEILSSYERAQNK