Protein Info for CSW01_12870 in Vibrio cholerae E7946 ATCC 55056

Annotation: aromatic acid decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02441: Flavoprotein
  • amino acids 8 to 192 (185 residues), 144.9 bits, E=8.8e-47
• TIGR00421: polyprenyl P-hydroxybenzoate and phenylacrylic acid decarboxylases
  • amino acids 9 to 202 (194 residues), 191.8 bits, E=4.4e-61

Best Hits

Swiss-Prot: 100% identical to UBIX_VIBCH: Flavin prenyltransferase UbiX (ubiX) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03186, 3-octaprenyl-4-hydroxybenzoate carboxy-lyase UbiX [EC: 4.1.1.-] (inferred from 100% identity to vco:VC0395_A2120)

MetaCyc: 60% identical to flavin prenyltransferase (Pseudomonas aeruginosa)
RXN-16937 [EC: 2.5.1.129]

Predicted SEED Role

"3-polyprenyl-4-hydroxybenzoate carboxy-lyase UbiX (EC 4.1.1.-)" in subsystem Ubiquinone Biosynthesis (EC 4.1.1.-)

MetaCyc Pathways

• superpathway of chorismate metabolism (51/59 steps found)
• superpathway of ubiquinol-8 biosynthesis (early decarboxylation) (10/12 steps found)
• ubiquinol-8 biosynthesis (early decarboxylation) (6/8 steps found)
• prenylated FMNH₂ biosynthesis (2/3 steps found)

KEGG Metabolic Maps

• 1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
• 1- and 2-Methylnaphthalene degradation
• 3-Chloroacrylic acid degradation
• Ascorbate and aldarate metabolism
• Benzoate degradation via hydroxylation
• Biphenyl degradation
• Fluorene degradation
• Phenylalanine metabolism
• Phenylpropanoid biosynthesis
• Purine metabolism
• Pyruvate metabolism
• Tryptophan metabolism
• Tyrosine metabolism
• Ubiquinone and menaquinone biosynthesis

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.-

Use Curated BLAST to search for 2.5.1.129 or 4.1.1.-

Protein Sequence (211 amino acids)

>CSW01_12870 aromatic acid decarboxylase (Vibrio cholerae E7946 ATCC 55056)
MSMNNNRTITLAWTGASGAPYGLRLLQCLLAADYQVYLLISSAARVVLATEHGLKLPANP
EAAQAALVEHLGCASDKLVVCGKEDWFSPVASGSAAPKQMVVCPCSAGSVAAIAHGMSDN
LIERAADVVLKERGQLLLVVRETPFSTLHLENMLKLSHMGVTIMPAAPGFYHQPQSIDDL
VDFMVARILDHLGIEQALVPRWGYDQRVRGE