Protein Info for CSW01_12785 in Vibrio cholerae E7946 ATCC 55056

Annotation: calcium/sodium antiporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 332 transmembrane" amino acids 6 to 30 (25 residues), see Phobius details amino acids 42 to 62 (21 residues), see Phobius details amino acids 83 to 104 (22 residues), see Phobius details amino acids 116 to 133 (18 residues), see Phobius details amino acids 139 to 157 (19 residues), see Phobius details amino acids 187 to 206 (20 residues), see Phobius details amino acids 212 to 212 (1 residues), see Phobius details amino acids 221 to 244 (24 residues), see Phobius details amino acids 252 to 274 (23 residues), see Phobius details amino acids 287 to 304 (18 residues), see Phobius details amino acids 312 to 330 (19 residues), see Phobius details TIGR00367: K+-dependent Na+/Ca+ exchanger homolog" amino acids 16 to 324 (309 residues), 280.4 bits, see alignment E=8.5e-88 PF01699: Na_Ca_ex" amino acids 17 to 157 (141 residues), 113.1 bits, see alignment E=5.8e-37 amino acids 187 to 329 (143 residues), 124.8 bits, see alignment E=1.5e-40

Best Hits

Swiss-Prot: 51% identical to CAXA_ALKAM: Putative antiporter CaxA (caxA) from Alkalimonas amylolytica

KEGG orthology group: K07301, inner membrane protein (inferred from 100% identity to vcm:VCM66_2444)

Predicted SEED Role

"Inner membrane protein YrbG, predicted calcium/sodium:proton antiporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (332 amino acids)

>CSW01_12785 calcium/sodium antiporter (Vibrio cholerae E7946 ATCC 55056)
MAFIFIYYVGINMLIEAVVFLFIGLAILVWGADKLVFGSAALARNIGISPLVIGMTILAM
GSSAPEMMVSATAALEGKTDTAVGNVLGSNIANIALILGITAIVKPLSVGSAVLRRELPM
MIGVTLIAGAILWDNHLGFYEGILLIALFAAFILVMLQVSRKEKQNGDALLDEQESEIPV
GVSNPKAAFWVVVGLILLPIGAGMLVDNAVVIAKYFGMSDLVIGLTIIAVGTSLPELAAS
LAGALKGEDDMAVGNIIGSNVFNILAVMGLPGLLNPSLLSPEAMSRDFWVMLGVSLLLVG
VALGKKRQITRLEGALLLCSFIGYITYLLMNI