Protein Info for CSW01_12450 in Vibrio cholerae E7946 ATCC 55056

Annotation: GTPase Era

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR00231: small GTP-binding protein domain
  • amino acids 31 to 191 (161 residues), 127.4 bits, E=4.6e-41
• TIGR00436: GTP-binding protein Era
  • amino acids 32 to 304 (273 residues), 364.8 bits, E=2.6e-113
• PF02421: FeoB_N
  • amino acids 34 to 191 (158 residues), 58.1 bits, E=3.1e-19
• PF00009: GTP_EFTU
  • amino acids 34 to 197 (164 residues), 32.5 bits, E=2.7e-11
• PF01926: MMR_HSR1
  • amino acids 34 to 148 (115 residues), 89.9 bits, E=5e-29
• PF10662: PduV-EutP
  • amino acids 35 to 193 (159 residues), 23.1 bits, E=2.3e-08
• PF04548: AIG1
  • amino acids 35 to 137 (103 residues), 29.2 bits, E=2.2e-10
• PF07650: KH_2
  • amino acids 232 to 309 (78 residues), 70.3 bits, E=4.1e-23

Best Hits

Swiss-Prot: 100% identical to ERA_VIBCH: GTPase Era (era) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03595, GTP-binding protein Era (inferred from 100% identity to vcm:VCM66_2383)

MetaCyc: 71% identical to 30S ribosomal subunit maturation GTPase Era (Escherichia coli K-12 substr. MG1655)
3.6.1.15,3.6.5.6,3.6.5.5,3.6.5.4,3.6.5.3,3.6.5.2,3.6.5.1,3.6.1.-,3.6.1.5 [EC: 3.6.1.15, 3.6.1.5, 3.6.5.1, 3.6.5.2, 3.6.5.3, 3.6.5.4, 3.6.5.5, 3.6.5.6]

Predicted SEED Role

"GTP-binding protein Era" in subsystem Bacterial Cell Division or Universal GTPases

MetaCyc Pathways

• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (17/18 steps found)
• superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis (E. coli) (12/14 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis I (8/9 steps found)
• pyrimidine deoxyribonucleotides biosynthesis from CTP (7/8 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis IV (6/7 steps found)
• pyrimidine deoxyribonucleotides de novo biosynthesis III (7/9 steps found)
• UTP and CTP dephosphorylation I (5/7 steps found)
• UTP and CTP dephosphorylation II (1/3 steps found)

KEGG Metabolic Maps

• Purine metabolism
• Pyrimidine metabolism
• Thiamine metabolism

Isozymes

Compare fitness of predicted isozymes for: 3.6.1.15

Use Curated BLAST to search for 3.6.1.15 or 3.6.1.5 or 3.6.5.1 or 3.6.5.2 or 3.6.5.3 or 3.6.5.4 or 3.6.5.5 or 3.6.5.6

Protein Sequence (325 amino acids)

>CSW01_12450 GTPase Era (Vibrio cholerae E7946 ATCC 55056)
MADQEFDIDAYFASQSEGKSVVASTPENQHCGFVAIVGRPNVGKSTLLNNLLGQKISITS
RKPQTTRHRIMGVETDGNYQAIYVDTPGLHIEEKRAINRLMNRAASSSLSDVNLVLFVVE
GTHWTADDEMVFTKLQKANFPVVLCVNKVDQVKDRNEVMLHMLELSKRMQFVDIVPISAK
QGKNTDVLKKHVRDHLPKAVHHFPEEYVTDRSQRFMASEIVREKLMRFTGEELPYSVTVE
IERFDYNPDTDGFHINALILVERIGQKKMVIGKNGEKIKTIGREARLDMEELFGRKVYLE
TWVKVKSGWADDERALRSLGYIDDL