Protein Info for CSW01_12380 in Vibrio cholerae E7946 ATCC 55056

Annotation: general secretion pathway protein GspA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 529 transmembrane" amino acids 285 to 305 (21 residues), see Phobius details PF13191: AAA_16" amino acids 26 to 155 (130 residues), 40.1 bits, see alignment E=1.4e-13 PF13401: AAA_22" amino acids 42 to 171 (130 residues), 92.8 bits, see alignment E=5.7e-30 PF00004: AAA" amino acids 47 to 174 (128 residues), 23.8 bits, see alignment E=1.3e-08 PF21327: GspA_C39-like" amino acids 351 to 445 (95 residues), 84.4 bits, see alignment E=1.5e-27 PF01471: PG_binding_1" amino acids 458 to 514 (57 residues), 38.4 bits, see alignment 2.9e-13

Best Hits

KEGG orthology group: K02450, general secretion pathway protein A (inferred from 100% identity to vco:VC0395_A2023)

Predicted SEED Role

"General secretion pathway protein A"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (529 amino acids)

>CSW01_12380 general secretion pathway protein GspA (Vibrio cholerae E7946 ATCC 55056)
MYLNFFGFDELPFSIVPNARYLYLSQRHQEAIVHLQAGLGDGGGFAMLTGEVGTGKTTVA
RAILASLPGKTRAGMILNPTFSDLELLEAICDEFEVSYPKKATLKKLTQVLHEFLLAEHA
QGIQVLLMIDEAQHLAPDVLEQLRLLTNLETESHKLLKVLLIGQPELQEKLRLPQLRQLA
QRITGRYHLLPLNEEQTADYIRFRIEQASGNPELFNRKACQWIAEQTHGIPRLINLVCDA
ALKQAYQAGEPTLSLARIKLACQEVMSFQSSVYQVASAKPPVPKLSYLSSALGGIALAVV
LAWQLPPQLDRVMQHYFPLPEVVPPTEQRVFPQALRSALLNATSSEHALETLYAVWGYQA
SVLEQFCQTQADAVLWCEEQTGDWSTLQTYDLPAVLTLMMDDVPTYAVLYRLTGDQAELL
VGGERYRIARQWLEPLWNGQFSLLWQASFSRTLKQGMQGADVALLESKLAQVLGEPERPR
EQFDKDLSRKVELFQRWQNMHVDGIAGRQTLRRLELLTQQQAPSLKEEG