Protein Info for CSW01_12275 in Vibrio cholerae E7946 ATCC 55056

Annotation: type IV-A pilus assembly ATPase PilB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 562 TIGR02538: type IV-A pilus assembly ATPase PilB" amino acids 5 to 559 (555 residues), 801.7 bits, see alignment E=1.9e-245 PF05157: MshEN" amino acids 57 to 142 (86 residues), 58.8 bits, see alignment E=4.5e-20 PF00437: T2SSE" amino acids 177 to 558 (382 residues), 499.5 bits, see alignment E=4.7e-154

Best Hits

KEGG orthology group: K02652, type IV pilus assembly protein PilB (inferred from 100% identity to vco:VC0395_A2000)

Predicted SEED Role

"Type IV fimbrial assembly, ATPase PilB" in subsystem Type IV pilus

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (562 amino acids)

>CSW01_12275 type IV-A pilus assembly ATPase PilB (Vibrio cholerae E7946 ATCC 55056)
MLTNLVAILRQAELISATQEQAVVTQVSASGTSVPEALLELSIFHAQELTEQLSHIFGLP
ETDLSRYDYANLCQQLGLRELITRYDALPIAKQGNLLLLAVSDPTLLQAEEEFRFATGLQ
VELALADHRALQAAIRRLYGRSIQGAANQGKEISQDELANLVKVSDDELQSIEDLSQDDS
PVSRFINQVLLDAVRKGASDIHFEPYENQYRIRLRCDGILVETQQPASHLSRRLAARIKI
LSKLDIAERRLPQDGRIKLRLSRDTAIDMRVSTLPTLWGEKIVLRLLDSSAANLDIDKLG
YNPQQKQLYLNALKRPQGMILMTGPTGSGKTVSLYTGLRILNTSQINISTAEDPVEINLS
GINQVQVQPKIGFGFAEALRSFLRQDPDVVMVGEIRDLETAEIAVKAAQTGHLVLSTLHT
NSAAETVIRLANMGVEPFNLASSLSLIIAQRLARRLCKHCKIAVRPSALLQSQFAFQPNE
ILYEANAAGCNECTGGYSGRVGIYEVMAFNTELAEAIMQRASIHQIERLAKANGMQTLQE
SGLEKLREGITSFAELQRVLYF