Protein Info for CSW01_11955 in Vibrio cholerae E7946 ATCC 55056

Annotation: endonuclease

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 286 TIGR00587: apurinic endonuclease (APN1)" amino acids 4 to 279 (276 residues), 350.9 bits, see alignment E=2.4e-109 PF01261: AP_endonuc_2" amino acids 22 to 279 (258 residues), 211 bits, see alignment E=1.2e-66

Best Hits

Swiss-Prot: 100% identical to END4_VIBC3: Probable endonuclease 4 (nfo) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K01151, deoxyribonuclease IV [EC: 3.1.21.2] (inferred from 100% identity to vch:VC2360)

MetaCyc: 69% identical to endonuclease IV (Escherichia coli K-12 substr. MG1655)
3.1.4.-; 3.1.4.-; 3.1.3.-; Deoxyribonuclease IV (phage-T(4)-induced). [EC: 3.1.21.2]; 3.1.21.- [EC: 3.1.21.2]

Predicted SEED Role

"Endonuclease IV (EC 3.1.21.2)" in subsystem DNA repair, bacterial (EC 3.1.21.2)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.21.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (286 amino acids)

>CSW01_11955 endonuclease (Vibrio cholerae E7946 ATCC 55056)
MYEKLIGAHVSASGGVELAPVRAHEIGANAFALFTKNQRQWAAKPLEASSIRAFKANCKK
WGFGSEAILPHDSYLINLGAPEPEKLDKSRAAFVDEMLRCDQLGLTLLNFHPGSHLQQVS
EEACLATIAESINLAHRQVPNVIAVIENTAGQGSNLGWRFEHLAAIIDQVEDKERVGVCL
DTCHTFAAGYDLRTKAACDETFAEFERVVGMHYLRAMHINDSKGKLASRVDRHHSLGMGE
IGWECFEYIAQDARFNGIPLILETIDPDIWATEIATLRKFSTQKEN