Protein Info for CSW01_11865 in Vibrio cholerae E7946 ATCC 55056

Annotation: elongation factor G

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 695 TIGR00484: translation elongation factor G" amino acids 3 to 689 (687 residues), 983.3 bits, see alignment E=5.5e-300 PF00009: GTP_EFTU" amino acids 7 to 278 (272 residues), 198.2 bits, see alignment E=2.5e-62 TIGR00231: small GTP-binding protein domain" amino acids 8 to 174 (167 residues), 86 bits, see alignment E=2.5e-28 PF03144: GTP_EFTU_D2" amino acids 321 to 388 (68 residues), 71.6 bits, see alignment E=1.5e-23 PF14492: EFG_III" amino acids 401 to 474 (74 residues), 99.3 bits, see alignment E=2.6e-32 PF03764: EFG_IV" amino acids 476 to 594 (119 residues), 149.9 bits, see alignment E=7e-48 PF00679: EFG_C" amino acids 597 to 683 (87 residues), 98.3 bits, see alignment E=5.4e-32

Best Hits

Swiss-Prot: 100% identical to EFG2_VIBCH: Elongation factor G 2 (fusA2) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K02355, elongation factor G (inferred from 88% identity to mme:Marme_2319)

Predicted SEED Role

"Translation elongation factor G paralog" in subsystem Translation elongation factor G family

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (695 amino acids)

>CSW01_11865 elongation factor G (Vibrio cholerae E7946 ATCC 55056)
MADLSLYRNIGIFAHVDAGKTTTTERILKLTGKIHRLGEVHDGASTMDFMEQEAERGITI
QSAATTCFWKGHRFNVIDTPGHVDFTVEVYRSLKVLDGGIGVFCGSGGVEPQSETNWRYA
NESEVSRLIFVNKLDRMGADFFRVVEQVKKVLGANPLVMTLPIGREDEFVGVVDVLTRQA
YVWDDSGLPENFEVKEVPADMVDQVEEYREMMIETAVEQDDELMMAYMEGEEPTVEQIKA
CIRKGTRDLAFFPTFCGSAFKNKGMQLVLDAVVDYLPSPTEVEPQPLTDPATGEPTGEVA
TVSVDAPLKALAFKIMDDRFGALTFVRIYSGKIKKGDTILNSATGKTERIGRMVEMHAND
RNEVESAQAGDIIAIVGMKNVQTGHTLCDPKHECTLEPMIFPTPVISIAVKPKDKNGSEK
MGIAIGKMVAEDPSFQVETDEDSGETILKGMGELHLDIKVDILKRTYGVELEVGAPQVAY
RETITKAVEDSYTHKKQSGGSGQFGKIDYRIRPGEQNSGFTFKSTVVGGNVPKEFWPAVE
KGFKSMMDTGTLAGFPVLDVEVELFDGGFHAVDSSAIAFEIAAKGAFRQSIPKAAPQLLE
PIMKVDVFTPEDHVGDVIGDLNRRRGMIKDQEMGLTGVRVKADVPLSEMFGYIGSLRTMT
SGRGQFSMEFSHYAPCPNNVAEQVIAEVKERNAKK