Protein Info for CSW01_11855 in Vibrio cholerae E7946 ATCC 55056

Annotation: HD-GYP domain-containing protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 384 PF13487: HD_5" amino acids 188 to 353 (166 residues), 105.5 bits, see alignment E=1.4e-34

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcm:VCM66_2263)

Predicted SEED Role

"Response regulator containing a CheY-like receiver domain and an HD-GYP domain"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (384 amino acids)

>CSW01_11855 HD-GYP domain-containing protein (Vibrio cholerae E7946 ATCC 55056)
MQMQPKVGQFRYYPSVGSLNTYLTNMLEKIRVELPDIQRISFALYDEKKDSIKTCADSSP
VSHDFVHYELPLANLPSLQQSKESGALRIIHDLANQAKSHTPHNRWLLEQQYCSSLVKPV
FDQHTFVGFLFFNASMSHYFSASVVERLETYLSLIQQSICGEYALIHQLVDHVHQIETQS
PEHWLHIKQHKERISRYARIIALDVADQYALDDELIENISQFATCHDLGKLALPADLLQK
RASLANHEKEQVHNHIEYGIDLLNEVIAKLGTPHHPCLAVLREIMAYHHEFLDGSGYPFG
LVSDQIPIPARIIAVANIFDALTAHRPYKQAQSIPHALLELEKMVSDGKLDRHCVNALRE
NQEELKEIVARFPEQDPKDQGITH