Protein Info for CSW01_11810 in Vibrio cholerae E7946 ATCC 55056

Annotation: short-chain dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 414 transmembrane" amino acids 44 to 63 (20 residues), see Phobius details amino acids 83 to 100 (18 residues), see Phobius details amino acids 112 to 130 (19 residues), see Phobius details amino acids 135 to 154 (20 residues), see Phobius details amino acids 165 to 185 (21 residues), see Phobius details amino acids 200 to 220 (21 residues), see Phobius details amino acids 232 to 253 (22 residues), see Phobius details amino acids 259 to 276 (18 residues), see Phobius details amino acids 288 to 306 (19 residues), see Phobius details amino acids 318 to 336 (19 residues), see Phobius details amino acids 355 to 374 (20 residues), see Phobius details amino acids 380 to 400 (21 residues), see Phobius details PF05940: NnrS" amino acids 36 to 408 (373 residues), 362.2 bits, see alignment E=2.1e-112

Best Hits

KEGG orthology group: K07234, uncharacterized protein involved in response to NO (inferred from 100% identity to vch:VC2330)

Predicted SEED Role

"NnrS protein involved in response to NO" in subsystem Denitrification or Nitrosative stress or Oxidative stress

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (414 amino acids)

>CSW01_11810 short-chain dehydrogenase (Vibrio cholerae E7946 ATCC 55056)
MAWFVLITGSVCDEVGEGAKVINIIDKRVEERIPAVLRLGFRPFFLLGSIYAVIAILAWV
WMFQAGQPQLLQVPALWWHVHEMLFGFAMAIVAGFLLTAVQNWTGITGTKSHRLAGIVAL
WLMVRILFWLPVPLWLTSSIEALFLLAVAYEVGLRVVKAKGWRNLFFIPLFLLAIAANFA
SYATIKGMPPFPSSAVWQAMLWWFMLLLSVMGGRVIPFFTARRFQFTKAEPILALDVIAN
GSLLALFVLSFFPLTMAQLGQPLMLVAGVAQLIRFLRWQPWRTFSEPLVWSLHAAYLCIP
LSLLLRGGVSNAWLNHNLLHLFAIGALSGLVLSMIARVTMGHTGRAIYQGPNMQWAFIAL
LLAAVVRGVGVGLLPQQLLIWVNLSAALWVIAFALFVLRFGAMLLKPRVDGHPG