Protein Info for CSW01_11775 in Vibrio cholerae E7946 ATCC 55056

Annotation: exodeoxyribonuclease V subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 706 TIGR01447: exodeoxyribonuclease V, alpha subunit" amino acids 10 to 704 (695 residues), 851.3 bits, see alignment E=2.1e-260 PF21185: RecD_N" amino acids 14 to 126 (113 residues), 52.5 bits, see alignment E=2.5e-17 PF13245: AAA_19" amino acids 237 to 389 (153 residues), 125.2 bits, see alignment E=1.1e-39 PF13604: AAA_30" amino acids 239 to 399 (161 residues), 93.4 bits, see alignment E=7.9e-30 PF00580: UvrD-helicase" amino acids 240 to 327 (88 residues), 30 bits, see alignment E=2.2e-10 PF05127: Helicase_RecD" amino acids 251 to 372 (122 residues), 36.9 bits, see alignment E=1.8e-12 PF18335: SH3_13" amino acids 551 to 612 (62 residues), 48.3 bits, see alignment 3.5e-16 PF13538: UvrD_C_2" amino acids 633 to 679 (47 residues), 46.1 bits, see alignment 1.7e-15

Best Hits

KEGG orthology group: K03581, exodeoxyribonuclease V alpha subunit [EC: 3.1.11.5] (inferred from 100% identity to vch:VC2319)

Predicted SEED Role

"Exodeoxyribonuclease V alpha chain (EC 3.1.11.5)" in subsystem DNA-replication (EC 3.1.11.5)

Isozymes

Compare fitness of predicted isozymes for: 3.1.11.5

Use Curated BLAST to search for 3.1.11.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (706 amino acids)

>CSW01_11775 exodeoxyribonuclease V subunit alpha (Vibrio cholerae E7946 ATCC 55056)
MMFWDSEVAKRLLAQGALRPLDVQFARFIGKQAVLAGHNAAESELLSVLSAALSAELGRG
HICLPLCDAQGNRCDLAALIGLYGEASLQHSERWLAVDWQALLQASPLVGQQGEAVPLMF
DGSRLYLHRYWHYEKQLAARLTELAAPQRLSPAELANLRERLNTLFARDYLGLWQALQQK
PLSSVERIQLLNDRLDVVESDALDWPAIEAVVEKAQRAADLQALEQLIPLTHCLNWQKVA
AAVALTRRFAVISGGPGTGKTTTVTKLLAALISQSMAQGKVPEIKLIAPTGKAAARLTES
MGKAVSQLAIEPEIAAAIPSSSSTIHRLLGAIPGSAEFRHHTRNPLHLDLLVVDEASMVD
LPLMVKLVEALPKHARLILLGDKDQLASVEAGAVLGDICTFLNQGYGHEQGAQLAELTGF
ATLRQTASKTVNPVADCLCMLQKSYRFDARSGIGQLAKAINSGSPARVEAVWQQSFSDIE
HFALSGEHYQQLLQTLVQAYRPYLSLLNQPTEQFESTQQSMLTLAKSALDAFSRCRLLCA
LREGDFGVMGLNTRIERALNAHKLIKTQEEIWYHGRPIMVTRNDHGLGLYNGDIGLCMRD
RDDDQGRLKVYFELPDGSIKAVLPSRVPQHETAYAMTIHKSQGSEFDLTLLILPPDYSPI
LTRELVYTGITRAKKQLKLYCDNKVLQRAIKVKTQRASGLVARLEQ