Protein Info for CSW01_11270 in Vibrio cholerae E7946 ATCC 55056

Annotation: non-ribosomal peptide synthetase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2000 2200 2413 transmembrane" amino acids 959 to 975 (17 residues), see Phobius details amino acids 1094 to 1112 (19 residues), see Phobius details PF00668: Condensation" amino acids 26 to 440 (415 residues), 111 bits, see alignment E=1.3e-35 amino acids 454 to 867 (414 residues), 44.9 bits, see alignment E=1.4e-15 amino acids 1422 to 1571 (150 residues), 31.2 bits, see alignment 2e-11 amino acids 1948 to 2371 (424 residues), 159 bits, see alignment E=3.4e-50 PF00501: AMP-binding" amino acids 907 to 1250 (344 residues), 247.8 bits, see alignment E=3.3e-77 TIGR01733: amino acid adenylation domain" amino acids 922 to 1325 (404 residues), 346.5 bits, see alignment E=9.4e-108 PF13193: AMP-binding_C" amino acids 1310 to 1384 (75 residues), 27.8 bits, see alignment (E = 7.8e-10) PF00550: PP-binding" amino acids 1865 to 1925 (61 residues), 36.4 bits, see alignment (E = 9.9e-13)

Best Hits

KEGG orthology group: K12237, nonribosomal peptide synthetase VibF (inferred from 100% identity to vch:VC2209)

Predicted SEED Role

"Non-ribosomal peptide synthetase modules, siderophore biosynthesis" in subsystem Iron acquisition in Vibrio

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (2413 amino acids)

>CSW01_11270 non-ribosomal peptide synthetase (Vibrio cholerae E7946 ATCC 55056)
MKEMTAMQAAYWLGRQHDCLLDGVAAHLYAEFDGQALNRQALTEAVRALYAKHPMLRLAI
TKDGQQKILPLSTFHQLKVDDLSQWKPDEVESFVHTKRQRMTHQMLDLTQGNPIEISLTL
LPEGKHRLHIDADMIACDAQSFRLLVDDLTSLYLEAIEHRLEIIESDVVTFFQYLDAQQA
DRALAKRKEVDKKWWQERLATIPAEPSLPYQPVPTDAVSANSQRFAHWFTPVERKGLAEV
ARQHHLTLTQLTLALFSQVIANACQERQFRLNVPTFHRGNRSLDIEHTIGDFSNLLIFSA
DVGTTQTLLSLCQQTANQLHQLLRHESYSGVSVMRDLSRKQGGVQRSPIVFTSGMEMRDE
EIFSDHVTQHLGRMNWVISQGAQVTLDAQIAPAYEGILLNWDVRMENFADKDITALFAHY
VDLIRCVALHPEMMQQSVQQIDAQLGYARRESIQEMPLTPLQQAYLLGRSTQIALGGVAM
HEFREYRGHIDTQSLHSRLLYLVEHIPALRTRIDQEKWIQWVSPCIALNWQAIDLQHLSR
EQALLAVEPVRQQYQQRMHDLTRSPWQICVVQLPIEEQEEFSSIVLTSFDALIVDGRTHA
LILAALLGSEEPDITQVVQNARDTQSISPQFASKKAQDEAYWKSKLHPDCPPPALPWKQA
LETITTSRYARESLQIPKESVGKLNRCGIENGLFLNSLLTATILDVLSYWTTEIGMRVGF
PVLIPSSNAIDGNESSFVILEHEKSTLSLLSQASKLQREMLEALEHLAFSGVDLNRLLMN
QAPQALVLPVVLTNGLSWKTLNPEDAVTLFDGVTQTPQVALDIRLTYDEQKNLIISFDYA
LAVLETELIREMLSALHHRLSQITSSASLAAPLEPCIDLSHYRFNSDESASHDCDFLAKL
AQQLFVRTEDKTAVICGEQTLSYAQLGEQVQRVMWQLKARGLTTGNVLAICLPRSVEHIV
ISLASALSGIIWVPIDAASPKERLNYLLENCHADLVVMDKPCEFGNVIAFDALIEPVLFA
DGVPDVTPLDQLSRLSQSQQTAYYLYTSGTTGKPKCVVVNNQATSNVIGQTGQAWHLTSE
DVVMSVTPLHHDMSVFDLFATLSFGATLVLPAGHEEKDALQWNRLIERHQVTIWVSVPAI
LEMLLSCTQAGQLHSLRLIAQGGDYIKPATIAQLRAGSNPPRLISLGGPTETTIWSIWHE
LTADDVSVIPYGRPLAGNRYFIMDEIQRHVPQGVVGRIFTSGVNLAQGYLEDGELKQTDF
VTVLDEHGHPVRAFRTGDQGYYRADGNIIFASRINGYVKVRGVRVSLPDIEKQLQTHPAL
ASVVVVDYADTNGDTALAALFSVKPQQSASSQALREFAKQSLPSSHIPSRFIALEALPLS
ANGKVDRKQCQAHVQRQSISVEPVGQPNQSQPLSPPTLSSASLSEFEQRVWRQHQRHGDG
RNQYATAYRLSGKVNIARLITALSQLPNHFPVLNRRYVLDEASGLTLYSAKPTPLEIHFE
HVESMDEAFEHLVRWQNQPMDLAKQATLSFCLLSLGSEERVLGVISHQIISEQWDWRRVF
ECVTNGYNQIACDIDPVMEGEDLSLGFTPVMPQTPLSQALLPWLQPASHATWIEQSLPSA
NSAINTLCSRKYRIALHSSVLAEHGLAQPDKQEVLALIAALFARYLAASAKLGQFELYVP
HDVERKTRELNGSMIESQLVHIALKGFERPLSQLSQEILDAMRQPLTGGVASETHASAAA
LVTWLVDPSVHLQLEGLRCEKLLFAAMHPKFEVALGVGLNCQGALVLELALDATVSPHVG
AYLLEQFVAAIGGRTMPSSTTSSSHVSAIELTSNNPPTSNNAHAALAESELELSAVNSSA
VEECILAEFRSALGVAEMTAEDDFFDFGGHSLIATRVIGRLLSEQGIELHINDMFSFPNA
KQLAQQAVLHRKPTSTSFAVSEVVESSKAPLSLAQASLWKAMSKYAKFGLTHIFNLPFAL
KFLDEVNEQAFGEAFHWLLLRHAGLRTHFGLEDGQPYQHVIAASNIEHYQWFWTSKDNAA
QSVARLLAQEAEHTFDLSQELPLRLNFVRDEQTGTQYLSLLFHHIVLDEWSINILMDELA
QVYQHSVQGTRPQWQTEPLPFHEFARKQRSSAFNQTHLNYWLTKFAGVPWAQPLFAADHP
LSNSTGVDLGEGGWVEIKLPKSTMVSLYQLAKARHASLFNVMYAAISASVHCLGAPEKLL
VGTPASGRLDAEFFDTVGYFTTMGVQLVDFTKVQTVWQLIEQVKNSINQSMPYTDIPIDL
IEEGLKGVEHETEGHMFEVFIQLHAKNKLHGELLLTEGHAIRFQQVDPDKSESGLGLQFE
ILEERIEQKQTLRVMMSYMSKHYSPAQVALLTKVTSGMFERFSDCIAQDIALPTLKKQVR
QLEDEACRSPSMG