Protein Info for CSW01_10845 in Vibrio cholerae E7946 ATCC 55056

Annotation: peptide chain release factor 1

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 362 TIGR00019: peptide chain release factor 1" amino acids 1 to 359 (359 residues), 569.6 bits, see alignment E=1.2e-175 PF03462: PCRF" amino acids 13 to 205 (193 residues), 269.3 bits, see alignment E=2e-84 PF00472: RF-1" amino acids 218 to 323 (106 residues), 145.6 bits, see alignment E=6.2e-47

Best Hits

Swiss-Prot: 100% identical to RF1_VIBC3: Peptide chain release factor 1 (prfA) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K02835, peptide chain release factor 1 (inferred from 100% identity to vch:VC2179)

Predicted SEED Role

"Peptide chain release factor 1" in subsystem LMPTP YwlE cluster

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (362 amino acids)

>CSW01_10845 peptide chain release factor 1 (Vibrio cholerae E7946 ATCC 55056)
MKASILSKLESLVERYEEVQHLLGDPTVIGDQNKFRALSKEYSQLEEITQCFQAYQQAKE
DLVAAEEMAQEDDAEMREMAQDEIKAAKAAIERLTDELQILLLPKDPNDDRNCFLEIRAG
AGGDEAGIFAGDLFRMYSRFAEKKGWRIEVMSSSEAEHGGYKEMIAKVNGDGAYGTLKFE
SGGHRVQRVPATEAQGRIHTSACTVAVMPEIPEAEIPEIKASDLKIDTFRSSGAGGQHVN
TTDSAIRITHLPTGIVVECQDERSQHKNKAKAMSVLAARIAQAEESKRAAEISDTRRNLL
GSGDRSDRIRTYNYPQGRVSDHRINLTVYRLTEVMEGDMQSLIDPVIHEHQADQLAALAD
QN