Protein Info for CSW01_10385 in Vibrio cholerae E7946 ATCC 55056

Annotation: Fe(2+) transporter permease subunit FeoB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 758 transmembrane" amino acids 280 to 308 (29 residues), see Phobius details amino acids 331 to 364 (34 residues), see Phobius details amino acids 420 to 444 (25 residues), see Phobius details amino acids 451 to 470 (20 residues), see Phobius details amino acids 508 to 527 (20 residues), see Phobius details amino acids 664 to 685 (22 residues), see Phobius details amino acids 693 to 713 (21 residues), see Phobius details amino acids 725 to 743 (19 residues), see Phobius details PF02421: FeoB_N" amino acids 4 to 161 (158 residues), 192.6 bits, see alignment E=9.6e-61 PF01926: MMR_HSR1" amino acids 5 to 120 (116 residues), 73.9 bits, see alignment E=3.4e-24 TIGR00437: ferrous iron transport protein B" amino acids 9 to 688 (680 residues), 592 bits, see alignment E=7.6e-182 PF17910: FeoB_Cyto" amino acids 179 to 257 (79 residues), 40.5 bits, see alignment E=9e-14 PF07670: Gate" amino acids 349 to 442 (94 residues), 81.3 bits, see alignment E=2e-26 amino acids 510 to 691 (182 residues), 66.7 bits, see alignment E=6.7e-22 PF07664: FeoB_C" amino acids 452 to 504 (53 residues), 68.5 bits, see alignment 1e-22

Best Hits

KEGG orthology group: K04759, ferrous iron transport protein B (inferred from 100% identity to vch:VC2077)

Predicted SEED Role

"Ferrous iron transport protein B" in subsystem Campylobacter Iron Metabolism or Iron acquisition in Vibrio or Transport of Iron

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (758 amino acids)

>CSW01_10385 Fe(2+) transporter permease subunit FeoB (Vibrio cholerae E7946 ATCC 55056)
MKYQVLTVGNPNSGKTTLFNGLTGAKQQVGNWAGVTVEKKTGSFVHAGDEFSLTDLPGIY
ALDSGNDSNSIDESIASRAVLTHPADVIINVVDATCLERSLYMTLQLRELRRPMIVVLNK
MDALKRERVHLDLKQLEAFLGCPVLALSANNKEQVRRFKEKLHKLLVQGIALKQIELHYG
AEFESLIHELEPMFAEQAVSARALAIRALENDRLVINGLKEAERQNVEQRQHECQVDIDL
LVANVRYTYLHELCTHVRRTEGKLSHKFTEKADRVILNKWVGIPFFFAVMYLMFMFSINI
GSAFIDFFDIGVGALLVDGGHHLLDDHLPVWLVTLIADGVGGGIQTVATFIPVIACLYLF
LAVLESSGYMSRAAFVLDKVMQKIGLPGKAFVPLVLGFGCNVPSIMATRTLDQERERKLA
ASMAPFMSCGARLPVYALFAAAFFPQSGQNVVFALYLLGIVAAVLTGLVLKKTLYPGVSE
SLIMDMPDYEIPTLQNVVIKTWQKLKRFVLGAGKTIVVVVTILSFLNSVGTDGSFGNENS
DKSVLSKAAQFVTPVFSPMGVTQENWPATVGIITGIFAKEAVVGTLNSLYTSTPDAEEAA
EYDLLASLQEALMTIPDNLAGLSFSDPLGIEVGDLTDTEAVAQEQEVDGSIFGNLHTYFA
NAHVAFAYLIFILLYTPCVAAMGAYVREFGAAYARFIAVWTMGLAYGSAVLYYQATHIAE
HPMYSLIWIGVIVGIGFATYWALKQTGRKQKMIEVSVA