Protein Info for CSW01_10180 in Vibrio cholerae E7946 ATCC 55056

Annotation: Na+/H+ antiporter NhaC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 481 transmembrane" amino acids 10 to 30 (21 residues), see Phobius details amino acids 36 to 55 (20 residues), see Phobius details amino acids 74 to 103 (30 residues), see Phobius details amino acids 110 to 132 (23 residues), see Phobius details amino acids 139 to 159 (21 residues), see Phobius details amino acids 194 to 215 (22 residues), see Phobius details amino acids 235 to 254 (20 residues), see Phobius details amino acids 259 to 277 (19 residues), see Phobius details amino acids 312 to 331 (20 residues), see Phobius details amino acids 351 to 376 (26 residues), see Phobius details amino acids 431 to 455 (25 residues), see Phobius details TIGR00931: Na+/H+ antiporter NhaC" amino acids 7 to 457 (451 residues), 542 bits, see alignment E=5.7e-167 PF03606: DcuC" amino acids 11 to 210 (200 residues), 25.7 bits, see alignment E=4.1e-10 PF03553: Na_H_antiporter" amino acids 161 to 453 (293 residues), 249.8 bits, see alignment E=3.9e-78

Best Hits

Swiss-Prot: 60% identical to MLEN_BACSU: Malate-2H(+)/Na(+)-lactate antiporter (mleN) from Bacillus subtilis (strain 168)

KEGG orthology group: K03315, Na+:H+ antiporter, NhaC family (inferred from 100% identity to vco:VC0395_A1622)

Predicted SEED Role

"Na+/H+ antiporter" in subsystem ZZ gjo need homes

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (481 amino acids)

>CSW01_10180 Na+/H+ antiporter NhaC (Vibrio cholerae E7946 ATCC 55056)
MLQAQQRLPSLTQVIVSLGLFLLLAFSFTAKLDLPIQLALYIGWFVIMTLGIRLGHKYKD
LENAALNGISNGLGAVLILLAVGALVGTWISGGIVPTIIYYGLKAIHPSIFLLATMVICS
LTALATGTSWGAAGTAGIAMMGIGQGLGIPAPITAGAVLSGCYFGDKMSPLSDSVILASS
MSNVEVMEHIKGMLPIALISYVITGILFTLFGFHYAGNVDMSQVETVIAAMEQQFYITPY
SFVPVLIVLGLLAMRMPSFPVISFGSLLGIVWAVMIQDVDFLQAFNTAWAPYNIESGVSF
IDAILNRGGMSSMLGSVAVIVFGLGFGGLLDRVGVLETIAKLFERRVTSPGSLATSTIGT
AFMGNVFGSAMYVSLILTPKICAKNYDRLGYQRKNLSRNAEFGGTLTSGMVPWSDNGIYM
ASILGVATLSYAPFMWLSFVCILVTIITSYCGWFVDKCEPTQAMNEQEVTAEEIQKAPAS
A