Protein Info for CSW01_10165 in Vibrio cholerae E7946 ATCC 55056

Annotation: bifunctional acetaldehyde-CoA/alcohol dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 5 to 400 (396 residues), 86.8 bits, E=1.9e-28
• PF00465: Fe-ADH
  • amino acids 458 to 848 (391 residues), 367.3 bits, E=1.1e-113
• PF13685: Fe-ADH_2
  • amino acids 469 to 554 (86 residues), 29.6 bits, E=9.2e-11
  • amino acids 604 to 737 (134 residues), 35.6 bits, E=1.4e-12

Best Hits

Swiss-Prot: 77% identical to ADHE_ECO57: Aldehyde-alcohol dehydrogenase (adhE) from Escherichia coli O157:H7

KEGG orthology group: K04072, acetaldehyde dehydrogenase / alcohol dehydrogenase [EC: 1.1.1.1 1.2.1.10] (inferred from 84% identity to avr:B565_1387)

MetaCyc: 77% identical to fused acetaldehyde-CoA dehydrogenase and iron-dependent alcohol dehydrogenasealdehyde/alcohol dehydrogenase AdhE (Escherichia coli K-12 substr. MG1655)
Acetaldehyde dehydrogenase (acetylating). [EC: 1.2.1.10]; Alcohol dehydrogenase. [EC: 1.2.1.10, 1.1.1.1]; 1.1.1.1 [EC: 1.2.1.10, 1.1.1.1]

Predicted SEED Role

No annotation

MetaCyc Pathways

• superpathway of N-acetylneuraminate degradation (20/22 steps found)
• mixed acid fermentation (15/16 steps found)
• hexitol fermentation to lactate, formate, ethanol and acetate (17/19 steps found)
• superpathway of L-threonine metabolism (15/18 steps found)
• superpathway of purine deoxyribonucleosides degradation (7/7 steps found)
• superpathway of pyrimidine deoxyribonucleosides degradation (6/6 steps found)
• superpathway of anaerobic sucrose degradation (15/19 steps found)
• 3-methylbutanol biosynthesis (engineered) (6/7 steps found)
• 2-aminoethylphosphonate degradation I (3/3 steps found)
• 2-deoxy-α-D-ribose 1-phosphate degradation (3/3 steps found)
• 2-deoxy-D-ribose degradation I (3/3 steps found)
• ethanol degradation II (3/3 steps found)
• pyruvate fermentation to ethanol I (3/3 steps found)
• pyruvate fermentation to ethanol III (3/3 steps found)
• L-threonine degradation IV (2/2 steps found)
• ethanol degradation I (2/2 steps found)
• superpathway of fermentation (Chlamydomonas reinhardtii) (7/9 steps found)
• acetylene degradation (anaerobic) (4/5 steps found)
• ethanolamine utilization (4/5 steps found)
• pyruvate fermentation to isobutanol (engineered) (4/5 steps found)
• acetaldehyde biosynthesis I (1/1 steps found)
• phytol degradation (3/4 steps found)
• heterolactic fermentation (13/18 steps found)
• 2-hydroxypenta-2,4-dienoate degradation (2/3 steps found)
• L-isoleucine degradation II (2/3 steps found)
• L-leucine degradation III (2/3 steps found)
• L-valine degradation II (2/3 steps found)
• pyruvate fermentation to ethanol II (1/2 steps found)
• (S)-propane-1,2-diol degradation (3/5 steps found)
• L-phenylalanine degradation III (2/4 steps found)
• L-tyrosine degradation III (2/4 steps found)
• L-methionine degradation III (1/3 steps found)
• sulfoacetaldehyde degradation IV (1/3 steps found)
• catechol degradation I (meta-cleavage pathway) (2/5 steps found)
• salidroside biosynthesis (1/4 steps found)
• serotonin degradation (3/7 steps found)
• phenylethanol biosynthesis (1/5 steps found)
• catechol degradation II (meta-cleavage pathway) (2/7 steps found)
• toluene degradation I (aerobic) (via o-cresol) (2/7 steps found)
• toluene degradation V (aerobic) (via toluene-cis-diol) (2/7 steps found)
• triethylamine degradation (1/6 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
• 3-phenylpropanoate and 3-(3-hydroxyphenyl)propanoate degradation (2/8 steps found)
• p-cumate degradation (2/8 steps found)
• butanol and isobutanol biosynthesis (engineered) (2/8 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)
• meta cleavage pathway of aromatic compounds (2/10 steps found)
• noradrenaline and adrenaline degradation (4/13 steps found)
• p-cymene degradation (2/11 steps found)
• L-tryptophan degradation IX (2/12 steps found)
• L-tryptophan degradation XII (Geobacillus) (2/12 steps found)
• naphthalene degradation to acetyl-CoA (2/12 steps found)
• toluene degradation IV (aerobic) (via catechol) (2/13 steps found)
• L-tryptophan degradation V (side chain pathway) (1/13 steps found)
• mandelate degradation to acetyl-CoA (2/18 steps found)
• superpathway of aerobic toluene degradation (2/30 steps found)
• superpathway of aromatic compound degradation via 3-oxoadipate (3/35 steps found)
• superpathway of aromatic compound degradation via 2-hydroxypentadienoate (4/42 steps found)

KEGG Metabolic Maps

• 1- and 2-Methylnaphthalene degradation
• 3-Chloroacrylic acid degradation
• Butanoate metabolism
• Drug metabolism - cytochrome P450
• Fatty acid metabolism
• Glycine, serine and threonine metabolism
• Glycolysis / Gluconeogenesis
• Metabolism of xenobiotics by cytochrome P450
• Pyruvate metabolism
• Retinol metabolism
• Tyrosine metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.1.1.1

Use Curated BLAST to search for 1.1.1.1 or 1.2.1.10

Protein Sequence (894 amino acids)

>CSW01_10165 bifunctional acetaldehyde-CoA/alcohol dehydrogenase (Vibrio cholerae E7946 ATCC 55056)
MPVTNLAELDALVARVKAAQAEFATFSQEQVDKIFRAASLAANQARIPLAQMAVEESGMG
IVEDKVIKNHFASEFIYNKYKDEKTCGILEEDDNLGTMTIAEPVGIICGIVPTTNPTSTA
IFKSLISLKTRNGIIFSPHPRAKNSTNAAAKLVLDAAIAAGAPKDIIGWIDQPSVELSNA
LMKHDGIALILATGGPGMVKAAYSSGKPAIGVGAGNVPVVIDETADIKRAVASILMSKTF
DNGVVCASEQAAIVVSEVYDEVKERFATHKAHVLSKADADKVRKVLLIDGALNAKIVGQP
AAAIAEMAGVKVPADTKVLVGEGLGKVSYDDEFAHEKLSPTLGLFRADNFEDAVAQAVTM
VEIGGIGHTSGLYTNQDVNADRIRYFGDKLKTARILVNIPTTHGGIGDLYNFNVAPSLTL
GCGSWGGNSISENVGPKHLINKKTVAKRAENMLWHKLPKSIYFRRGSLPIALSDLEGKKR
AFLVTDRFLFNNGYADDVVALLKAQGMEVQTFFEVEADPTLSVVEKGAAAMQSFQPDVIL
ALGGGSPMDAAKIMWVMYEHPDTHFEELAMRFMDIRKRIYKFPKMGKKAELVCITTTSGT
GSEVTPFAVVTDDKTGAKYPLADYELTPQMAIVDANLVMNMPKSLTAFGGYDAVTHALEA
YVSVLANEYSDGQALQALKMLKEYLPSSYANGAKDPIAREKVHNAATIAGIAFANAFLGV
CHSMAHKIGAEFHLPHGLANALLIANVVRYNANDNPTKQTAFSQYDRPQARRRYAEVADH
LGLSQPGDRTAQKIERLLTWLDELKVNLDIPKSIQAAGVAEADFLAKVDELAVEAFDDQC
TGANPRYPLIAELKEVLLASYYGKPFVEGQTFEGTTVIVKKADQEAAKAPKAKK