Protein Info for CSW01_10145 in Vibrio cholerae E7946 ATCC 55056

Annotation: ribonuclease E

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1052 transmembrane" amino acids 113 to 130 (18 residues), see Phobius details TIGR00757: ribonuclease, Rne/Rng family" amino acids 13 to 424 (412 residues), 567.5 bits, see alignment E=9e-175 PF00575: S1" amino acids 37 to 117 (81 residues), 43.6 bits, see alignment 4.6e-15 PF10150: RNase_E_G" amino acids 121 to 390 (270 residues), 334.5 bits, see alignment E=7.8e-104 PF20833: RNase_E_G_Thio" amino acids 402 to 486 (85 residues), 112.8 bits, see alignment E=1.1e-36

Best Hits

KEGG orthology group: K08300, ribonuclease E [EC: 3.1.26.12] (inferred from 100% identity to vcm:VCM66_1954)

Predicted SEED Role

"Ribonuclease E (EC 3.1.26.12)" in subsystem RNA processing and degradation, bacterial or Ribosome biogenesis bacterial (EC 3.1.26.12)

MetaCyc Pathways

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.1.26.12

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1052 amino acids)

>CSW01_10145 ribonuclease E (Vibrio cholerae E7946 ATCC 55056)
MKRMLINATQKEELRVALVDGQRLFDLDIESPGHESKKANIYKGRITRIEPSLEAAFVDY
GAERHGFLPLKEIAREYFPDGYSYQGRPNIKDVLNEGQEVIVQIEKEERGSKGAALTTFI
SLAGSYLVLMPNNPRAGGISRRIEGDERTELKSALSSLELPQGMGLIVRTAGVGKSAEEL
EWDLNVLLKHWSAIKQASDSNPAPFLIHQESNVIVRAIRDYLRRDIGEILIDSNSIYERA
LEHIRLVRPDFVNRVKKYEGEVPLFSHFQIESQIESAFQREVRLPSGGSIVIDPTEALTS
IDINSARATKGGDIEETALNTNLEAADEIARQLRLRDLGGLVVIDFIDMTPVRHQREVEN
RLREAVRVDRARVQIGRISRFGLLEMSRQRLSPSLAEASHHICPRCKGTGVIRDNESLAL
SVLRLIEEEALKDNTSQVLAVVPVSIASYLLNEKRRSINHIEKAQQVRITIVPNSDMETP
HFEVIRVREGEEQDVLSYLIPKKLEAMKEAEGKEVVDVELKPKRIEEPVLKGFAAPAEAV
PAPTPKPKAEPQPVAEVQQPAQPGFFSRVFKAIASLFSATPEAAKVEAPVTQNSEQDKPR
RERNDRNNDRRRNPRDKNRRRGNEENNERNDKETSNSNRKPQERKPKQERGERNERNDRN
ERPETERPERQDRRNKRDESKTAKLLEQGRQLAAEAQQEVKAVEPKEEKAAVVKERRQRR
KLSKQIRVKDQLAAEELDNLSTAPVDNAFDAPAPVNLPVTDDFADSAQEDNEQDDQKQRR
NRRSPRHLRASGQRRRRGRDRRPNPFRLRKGGVASPEMAMGKVMPRYDLAPRPQSRHETA
EGAQHVTHVTPTAATAVVESEKVAAPRVLGGVAFPEMAMGKVIVRRETAAVQPEPVVQEP
VITDVIAETLIAPVEPVVVEATVIEAPVIEESATETAALETVVAKVAEVEEPATISDEVV
AQTTVEVIADKMAEPIKVVKPVTVSATSLTAKAVIQQPYASSPMTKAPGSDDIREVQVNA
APLRAERYQARGAGSQVARNQASAGMSKPQSF