Protein Info for CSW01_10110 in Vibrio cholerae E7946 ATCC 55056

Annotation: phosphate acyltransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02504: FA_synthesis
  • amino acids 5 to 327 (323 residues), 341.3 bits, E=2.7e-106
• TIGR00182: fatty acid/phospholipid synthesis protein PlsX
  • amino acids 6 to 335 (330 residues), 354.1 bits, E=3.9e-110

Best Hits

Swiss-Prot: 100% identical to PLSX_VIBC3: Phosphate acyltransferase (plsX) from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395)

KEGG orthology group: K03621, glycerol-3-phosphate acyltransferase PlsX [EC: 2.3.1.15] (inferred from 100% identity to vco:VC0395_A1610)

MetaCyc: 40% identical to acyl phosphate synthase subunit (Streptococcus pneumoniae R6)
RXN-9590 [EC: 2.3.1.274]

Predicted SEED Role

"Phosphate:acyl-ACP acyltransferase PlsX" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria

MetaCyc Pathways

• phosphatidylglycerol biosynthesis I (6/6 steps found)
• phosphatidylglycerol biosynthesis II (6/6 steps found)
• superpathway of phospholipid biosynthesis III (E. coli) (10/12 steps found)
• CDP-diacylglycerol biosynthesis I (4/4 steps found)
• CDP-diacylglycerol biosynthesis II (4/4 steps found)
• superpathway of cardiolipin biosynthesis (bacteria) (10/13 steps found)
• CDP-diacylglycerol biosynthesis III (4/5 steps found)
• oleate biosynthesis III (cyanobacteria) (2/3 steps found)
• phosphatidate biosynthesis (yeast) (3/5 steps found)
• diacylglycerol and triacylglycerol biosynthesis (3/7 steps found)
• palmitoyl ethanolamide biosynthesis (2/6 steps found)
• superpathway of stearidonate biosynthesis (cyanobacteria) (2/6 steps found)
• stigma estolide biosynthesis (2/7 steps found)
• anandamide biosynthesis II (2/8 steps found)
• anandamide biosynthesis I (3/12 steps found)
• superpathway of phospholipid biosynthesis II (plants) (10/28 steps found)

KEGG Metabolic Maps

• Glycerolipid metabolism
• Glycerophospholipid metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.3.1.15

Use Curated BLAST to search for 2.3.1.15 or 2.3.1.274

Protein Sequence (341 amino acids)

>CSW01_10110 phosphate acyltransferase (Vibrio cholerae E7946 ATCC 55056)
MQNLTVALDAMGGDFGPRVTVPAAVQALSHFPELKVILVGDQHQITQQLSLLGYSADTRL
SIVHSDRVISNSEKPSLALRHSAGSSMGMAIDLVAENQADACVSGGNTGALMALSRFRLK
LLPGIDRPALVSALPTISGRKTWMLDLGANVSSDADSLFQFAVMGAALAEQHLQQAPRVA
ILNIGAEEIKGNDLVKRCAEMLTQTQAINFIGYIEGNQLLTDAADVIVCDGFVGNVCLKA
CEGTAQLFIDKLKKSLLASSIKGWIARKLFSELFTELKTLNPDQYNGASLLGLRGIVIKS
HGSADVSAVVNAISEAVHEVKRQVPSRISDRLEAVLLERHY