Protein Info for CSW01_10045 in Vibrio cholerae E7946 ATCC 55056

Annotation: sodium-dependent transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 486 transmembrane" amino acids 12 to 29 (18 residues), see Phobius details amino acids 41 to 62 (22 residues), see Phobius details amino acids 84 to 109 (26 residues), see Phobius details amino acids 145 to 167 (23 residues), see Phobius details amino acids 179 to 200 (22 residues), see Phobius details amino acids 221 to 244 (24 residues), see Phobius details amino acids 256 to 281 (26 residues), see Phobius details amino acids 313 to 336 (24 residues), see Phobius details amino acids 356 to 379 (24 residues), see Phobius details amino acids 385 to 406 (22 residues), see Phobius details amino acids 425 to 445 (21 residues), see Phobius details amino acids 461 to 479 (19 residues), see Phobius details PF00209: SNF" amino acids 3 to 124 (122 residues), 140 bits, see alignment E=5.3e-45 amino acids 121 to 468 (348 residues), 270.9 bits, see alignment E=1.2e-84

Best Hits

Swiss-Prot: 45% identical to Y1319_METJA: Uncharacterized sodium-dependent transporter MJ1319 (MJ1319) from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)

KEGG orthology group: K03308, neurotransmitter:Na+ symporter, NSS family (inferred from 100% identity to vco:VC0395_A1598)

Predicted SEED Role

"Sodium-dependent transporter"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (486 amino acids)

>CSW01_10045 sodium-dependent transporter (Vibrio cholerae E7946 ATCC 55056)
MKREQWGSRVGFVLAAVGSAIGLGNIWRFPYMAYENGGGAFFIPYLFAMVTAGIPFMILE
FSMGQKHRGSAPTTLAKIHSKFEWLGWFQVGIAAVIAVYYVAVIGWAISYFGMSFTQSWG
SDTNAYFFSEYLKLGDNSPTNLGSIQWHIAFAMLIAWVITYAAIVGGVKKGIERASKIMM
PILFIMVLILIARMIFLPGALDGVNYMFQPDFSKIWDVKVWAAAYGQIFFTLSIGFAIML
AYSSYLPEKSDITNNAFMTVLINCGFSVLAGIMIFSVLGYMAQEQGKPLTEVVSAGVGLA
FVTLPAAINLLPIPYILGPLFFLALVVAGLSSHISIMEAVTSALIDKLGWSRKKAANIVI
GIGFLVSMAFATNGGLLLLDLVDHFANNVGIMASCLVELVLMTWLLKISDVRKYVNSISD
FSVGVWFDICLRFVSPVILAIIVATKLQALFTEGYGGYDLTLGWAIIAALLVIGILINAS
SRKEAY