Protein Info for CSW01_09750 in Vibrio cholerae E7946 ATCC 55056

Annotation: molybdopterin guanine dinucleotide-containing S/N-oxide reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 815 signal peptide" amino acids 1 to 32 (32 residues), see Phobius details TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 4 to 28 (25 residues), 25.5 bits, see alignment (E = 1.2e-09) TIGR00509: molybdopterin guanine dinucleotide-containing S/N-oxide reductases" amino acids 43 to 813 (771 residues), 1132.5 bits, see alignment E=0 PF00384: Molybdopterin" amino acids 86 to 555 (470 residues), 280.4 bits, see alignment E=3.1e-87 PF01568: Molydop_binding" amino acids 675 to 791 (117 residues), 89.7 bits, see alignment E=2e-29

Best Hits

Swiss-Prot: 70% identical to TORZ_ECOLI: Trimethylamine-N-oxide reductase 2 (torZ) from Escherichia coli (strain K12)

KEGG orthology group: K07812, trimethylamine-N-oxide reductase (cytochrome c) 2 [EC: 1.7.2.3] (inferred from 72% identity to cko:CKO_01828)

MetaCyc: 70% identical to trimethylamine N-oxide reductase 2 (Escherichia coli K-12 substr. MG1655)
Trimethylamine-N-oxide reductase (cytochrome c). [EC: 1.7.2.3]

Predicted SEED Role

No annotation

Isozymes

Compare fitness of predicted isozymes for: 1.7.2.3

Use Curated BLAST to search for 1.7.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (815 amino acids)

>CSW01_09750 molybdopterin guanine dinucleotide-containing S/N-oxide reductase (Vibrio cholerae E7946 ATCC 55056)
MTKITRRGFLKGTGMAAGAMAFTSFSPLSIASDNARGKGVLTAGRMGPLLCEVQDGKMVA
TKNALAQTVPNSLQSTGPDQVYTQARVKYPMVRKGFLANPAAPKGVRGSDEFVRVSWDDA
YRLIHEQHMRIRKTYGPASVFAGSYGWRSSGVLHKAQTLLQRYMSMAGGYSGHLGDYSTG
AAQIIMPHVVGSIEVYEQQTTYPVVLEHSDVVVLWGLNPINTLKIAWSSTDCAGLEFFHQ
LKKSGKTIIGIDPIRSETIEFFGEQAQWIAPHPMTDVAMMMGIAHSLIKQGKHDKAFLDK
YTVGYDRFEAYLLGKEDGVEKSAQWAEGICGVPAKQLETLAEIFSNHRTMLMAGWGMQRQ
QYGEQRHWMVVTLAAMLGQIGLPGGGFGFSYHYSNGGNPARDAGVLPAISAAIGGGSSAG
NDWAISGATQSFPVARIVEALENPGGAYQHNGHTLTFPEIKMIWWAGGANFTHHQDTNRL
IKAWQKPELIVISEPYWTAAAKHADIVLPITTTFERNDLTMTGDYSNQHLVPMKQVVEPQ
GEARNDFDVFADMAEMIRPGGRDVFTEGKTEMEWLYGFYKTAQKSGRAARVAMPNFSKFW
EDNQLIEMKWNAKNAQFVRYADFRADPILNPLGTPSGKIEIYSKTLAGFNLPDCPAHPTW
LAPDEFTGNAKQGELQLMTAHAAHRLHSQFNYAQLREEYAIANREPIWIHPEDAASRGIQ
TGDLVRAYNQRGQVLVGALVTDRIKQGSVCIHEGGWPDLDPQTGLCKNGGANVLTSDIPT
SRLANGCAANSSLVRIEKYTGPALELTAFMPPKNG