Protein Info for CSW01_09605 in Vibrio cholerae E7946 ATCC 55056

Annotation: endopeptidase La

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 786 PF02190: LON_substr_bdg" amino acids 10 to 199 (190 residues), 186.4 bits, see alignment E=1.9e-58 TIGR00763: endopeptidase La" amino acids 12 to 770 (759 residues), 1028.8 bits, see alignment E=0 PF00004: AAA" amino acids 351 to 489 (139 residues), 75.9 bits, see alignment E=1.3e-24 PF07728: AAA_5" amino acids 351 to 475 (125 residues), 35.7 bits, see alignment E=2.5e-12 PF22667: Lon_lid" amino acids 511 to 564 (54 residues), 80.2 bits, see alignment 2.1e-26 PF05362: Lon_C" amino acids 569 to 771 (203 residues), 330.4 bits, see alignment E=1.2e-102 PF13541: ChlI" amino acids 635 to 739 (105 residues), 28 bits, see alignment E=5.5e-10

Best Hits

Swiss-Prot: 92% identical to LON_VIBPA: Lon protease (lon) from Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)

KEGG orthology group: K01338, ATP-dependent Lon protease [EC: 3.4.21.53] (inferred from 85% identity to vsa:VSAL_I0821)

MetaCyc: 82% identical to Lon protease (Escherichia coli K-12 substr. MG1655)
Endopeptidase La. [EC: 3.4.21.53]

Predicted SEED Role

"ATP-dependent protease La (EC 3.4.21.53) Type I" in subsystem Proteasome bacterial or Proteolysis in bacteria, ATP-dependent (EC 3.4.21.53)

Isozymes

Compare fitness of predicted isozymes for: 3.4.21.53

Use Curated BLAST to search for 3.4.21.53

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (786 amino acids)

>CSW01_09605 endopeptidase La (Vibrio cholerae E7946 ATCC 55056)
MNLERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIQCLEAAMDNNKQVLLVAQKKAET
DEPKVADLFEVGTVATILQLLKLPDGTVKVLVEGQQRAKITQFYEEEYFFADAQYLVTPE
LDEREQEVVVRSAINQFEGFIKLNKKIPPEVLTSLNGIDEAARLADTIAAHMPLKLVDKQ
KVLELLDVSERLEFLMGQMESEIDLLQVEKRIRTRVKKQMEKSQREYYLNEQMKAIQKEL
GEMDDAPDEFETLKKKIEESKMPKEARDKAEQELHKLKMMSPMSAEATVVRSYIDWMVNV
PWTKRSKVKKDLSKAEEILNADHYGLERVKERILEYLAVQSRINKLKGPILCLVGPPGVG
KTSLGRSIAAATGRQYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLFL
LDEIDKMSSDMRGDPASALLEVLDPEQNNSFNDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAKDHLVSKQVERNGLKPSEIVIEDSAIVGIIRYYTREAGV
RGLEREISKICRKAVKKILLDKGVKTVVVNQQNLKEFLGVQRFDYGKAEESNRIGQVNGL
AWTEVGGDLLTIETQSMPGKGKLTQTGSLGDVMQESIQAAMTVVRSRAEKLGINPDFYEK
KDIHVHVPEGATPKDGPSAGIAMCTALVSSLTGNPVKAEVAMTGEITLRGEVLPIGGLKE
KLLAAHRGGIKTVLIPKDNERDLEEIPDNVIADLQVLPVQWIDEVLKVALEQDPTGVSFE
SKKSDA