Protein Info for CSW01_09520 in Vibrio cholerae E7946 ATCC 55056

Annotation: disulfide bond formation protein B

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 173 transmembrane" amino acids 15 to 35 (21 residues), see Phobius details amino acids 47 to 66 (20 residues), see Phobius details amino acids 74 to 88 (15 residues), see Phobius details amino acids 147 to 169 (23 residues), see Phobius details PF02600: DsbB" amino acids 14 to 162 (149 residues), 150 bits, see alignment E=3.3e-48

Best Hits

Swiss-Prot: 100% identical to DSBB_VIBCH: Disulfide bond formation protein B (dsbB) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K03611, disulfide bond formation protein DsbB (inferred from 99% identity to vco:VC0395_A1492)

MetaCyc: 48% identical to protein thiol:quinone oxidoreductase DsbB (Escherichia coli K-12 substr. MG1655)
RXN-19950 [EC: 1.8.5.9]

Predicted SEED Role

"Periplasmic thiol:disulfide oxidoreductase DsbB, required for DsbA reoxidation" in subsystem Biogenesis of c-type cytochromes or Periplasmic disulfide interchange

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.8.5.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (173 amino acids)

>CSW01_09520 disulfide bond formation protein B (Vibrio cholerae E7946 ATCC 55056)
MRILSSLKTFSQSRLSWLLLLAFVVFFTLCAMYFQHVMLLAPCVMCIYERIAMLGIGVAA
LIGAIAPQNPVVRWLGFAAWGASSYKGLMLAIEHVNYQFNPSPFATCDLFVTFPAWAPLN
QWAPNLFEAYGDCSKVVWQFLTLSMPQWLVVIFAANLLALAIFVVAQLAKTSR