Protein Info for CSW01_09135 in Vibrio cholerae E7946 ATCC 55056

Annotation: PTS fructose transporter subunit IIA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 621 transmembrane" amino acids 182 to 206 (25 residues), see Phobius details amino acids 221 to 243 (23 residues), see Phobius details amino acids 262 to 282 (21 residues), see Phobius details amino acids 301 to 324 (24 residues), see Phobius details amino acids 341 to 358 (18 residues), see Phobius details amino acids 378 to 400 (23 residues), see Phobius details amino acids 439 to 460 (22 residues), see Phobius details amino acids 478 to 498 (21 residues), see Phobius details PF00359: PTS_EIIA_2" amino acids 6 to 146 (141 residues), 118.6 bits, see alignment E=3.4e-38 TIGR00848: PTS system, fructose subfamily, IIA component" amino acids 8 to 133 (126 residues), 130.9 bits, see alignment E=4e-42 TIGR01427: PTS system, Fru family, IIC component" amino acids 176 to 496 (321 residues), 261.7 bits, see alignment E=1.8e-81 PF02378: PTS_EIIC" amino acids 188 to 446 (259 residues), 58.3 bits, see alignment E=1.1e-19 TIGR00829: PTS system, Fru family, IIB component" amino acids 528 to 610 (83 residues), 94.7 bits, see alignment E=4.9e-31 PF02302: PTS_IIB" amino acids 528 to 618 (91 residues), 65.2 bits, see alignment E=1.1e-21

Best Hits

KEGG orthology group: K11201, PTS system, fructose-specific IIA-like component [EC: 2.7.1.69] K11202, PTS system, fructose-specific IIB-like component [EC: 2.7.1.69] K11203, PTS system, fructose-specific IIC-like component (inferred from 100% identity to vch:VC1822)

Predicted SEED Role

No annotation

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.1.69

Use Curated BLAST to search for 2.7.1.69

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (621 amino acids)

>CSW01_09135 PTS fructose transporter subunit IIA (Vibrio cholerae E7946 ATCC 55056)
MDITHLIEPEIICLDLKANNKEDVLIELVELLDNAGKLTDKQQFLNDIWRREEIGNTGFE
EGIAIPHAKSAAVALPAVVVGISRQGIDYGAEDGQLSDVFFMLASPDGEDHHHIEVLAQI
SSKLIEEGFVEQLKAAESVEQALALFIHPQHSTLSSTQVMDYADYQPLSPMAQRLARVKE
HLLFGTSHMMPFIVAGGVLLSLSVMMSGHGAVPEEGVLADIAQMGIAGLTLFTVVLGGYI
AYSMADKPGLAPGMIGTWIAINQYQTGFIGAIIVGFFAGFVVRQLKRIALPDSMSSLGSI
FIYPLVGTFVTCGAVMWLIGAPIASSMLWLNQFLASMADSGKVVLGAVLGAMTAFDMGGP
INKVATLFAQTQVNTQPWLMGGVGIAICTPPLGMALATLLSPSKFKRDEREAGKAAGIMG
MIGISEGAIPFAAADPARVLPAIIAGGIVGNVIGFLFQVLNHAPWGGWIVLPVVDGKLGY
ILGTIAGALATALIAIALKKTVHEQDNEQGQSLAFSSVIGEGQADILAVTSCPSGVAHTF
LAAKSLEKAACLAGVKIKVETQGANGIINRITAKDVQRAKLVIFAHDVAIKEPERFKHIK
VIDVTTKDAILNAAALVQIKR