Protein Info for CSW01_08760 in Vibrio cholerae E7946 ATCC 55056

Annotation: NAD-dependent succinate-semialdehyde dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00171: Aldedh
  • amino acids 28 to 481 (454 residues), 548 bits, E=8.2e-169
• TIGR01780: succinate-semialdehyde dehydrogenase
  • amino acids 35 to 480 (446 residues), 672.6 bits, E=1.4e-206

Best Hits

Swiss-Prot: 58% identical to TGNE_ACIAD: Succinate semialdehyde dehydrogenase (tgnE) from Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1)

KEGG orthology group: K00135, succinate-semialdehyde dehydrogenase (NADP+) [EC: 1.2.1.16] (inferred from 100% identity to vch:VC1745)

MetaCyc: 61% identical to succinate-semialdehyde dehydrogenase (NAD+) (Alicycliphilus denitrificans)
Succinate-semialdehyde dehydrogenase. [EC: 1.2.1.24]

Predicted SEED Role

"Succinate-semialdehyde dehydrogenase [NAD(P)+] (EC 1.2.1.16)" (EC 1.2.1.16)

MetaCyc Pathways

• 4-aminobutanoate degradation I (2/2 steps found)
• 4-aminobutanoate degradation III (2/2 steps found)
• GABA shunt I (3/4 steps found)
• GABA shunt II (3/4 steps found)
• superpathway of 4-aminobutanoate degradation (2/3 steps found)
• 4-aminobutanoate degradation IV (1/3 steps found)
• N-methylpyrrolidone degradation (1/3 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Glutamate metabolism
• Tyrosine metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.2.1.16 or 1.2.1.24

Protein Sequence (488 amino acids)

>CSW01_08760 NAD-dependent succinate-semialdehyde dehydrogenase (Vibrio cholerae E7946 ATCC 55056)
MRSLAMLPTDFPFFHQSAFINGQWILGEPQARQTVTNPFDGSLIGSVPLLSAAQVQEAIA
GAQAAQILWCQQPAENKAKILRRWYELIEQHHESLAKLLTIEQGKPLAEARGEIHYAASF
VEWYAEEAKRAYGELIPSHKPDARIMVSRQPVGVVAAITPWNFPAAMITRKCAPAFAAGC
AVVLKPAPDTPFTALALADLAQQAGIPDGLLQVVTGDAIEIGRVLTESKTVRKLSFTGST
GVGKLLMAQSANNVKKLSLELGGNAPFIVFEDADINAAIDGVMVAKFRNAGQTCVCANRI
YVHDAVYDQFAAKLVDRVSRLNVGYGLDAGVNIGPLINDAAVAKVTSHIVDAQSKGAKVM
FGALPEAGSRLFQPHVLTEVTDEMRVADEETFGPLAALFRFSSEQEVIERANATDSGLAA
YCYTQSLRRAWHMSEALEAGIVGINEGLISTTLAPFGGIKESGLGREGAKHGLEEYLEVK
YTLMGGLA