Protein Info for CSW01_08400 in Vibrio cholerae E7946 ATCC 55056

Annotation: cystathionine beta-lyase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01053: Cys_Met_Meta_PP
  • amino acids 7 to 387 (381 residues), 398.4 bits, E=1.2e-123
• TIGR01324: cystathionine beta-lyase
  • amino acids 7 to 389 (383 residues), 567.5 bits, E=5.2e-175

Best Hits

Swiss-Prot: 61% identical to METC_SALTY: Cystathionine beta-lyase (metC) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K01760, cystathionine beta-lyase [EC: 4.4.1.8] (inferred from 100% identity to vcm:VCM66_1611)

Predicted SEED Role

"Cystathionine beta-lyase (EC 4.4.1.8)" in subsystem Methionine Biosynthesis (EC 4.4.1.8)

MetaCyc Pathways

• hydrogen sulfide biosynthesis II (mammalian) (1/6 steps found)

KEGG Metabolic Maps

• Biosynthesis of plant hormones
• Cysteine metabolism
• Methionine metabolism
• Nitrogen metabolism
• Selenoamino acid metabolism
• Sulfur metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 4.4.1.8

Protein Sequence (396 amino acids)

>CSW01_08400 cystathionine beta-lyase (Vibrio cholerae E7946 ATCC 55056)
MSEGKKTRLVTAGRNKKWTLGVVNPPVQRASTVVFDTVAQKNQAAINRANKTLFYGRRGT
TTHFAFQEAMVEIEGGAGCVLYPCGAAAITNAILSFVAQGDHILMVDTCYEPTRDFCEKV
LKKLGVSTTYYDPMLGEGIRELIQPNTKVLFTESPGSLTMEVQDIPTLSRIAHEHDIVVM
LDNTWAAGVLFSPFEHGVDISIQAATKYIVGHSDVMLGTAVANEKCWAQLREHSYLMGQY
ASPDDVYMAMRGLRTLDVRLRQHEQNSLQIAQWLQTRPEVDHVRHPALATCPGHEFFERD
FTGGNGLFSFVLKTTHPEATTALLDGMQHFSMGFSWGGFESLILAHEPKAFTSLRSVANP
HFCGTLLRVHIGLEDVEDLIADLEAGFARYNQILHA