Protein Info for CSW01_08395 in Vibrio cholerae E7946 ATCC 55056

Annotation: cardiolipin synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 484 transmembrane" amino acids 6 to 29 (24 residues), see Phobius details amino acids 36 to 58 (23 residues), see Phobius details TIGR04265: cardiolipin synthase" amino acids 8 to 484 (477 residues), 504.4 bits, see alignment E=1.9e-155 PF13396: PLDc_N" amino acids 22 to 59 (38 residues), 33 bits, see alignment 7.2e-12 PF13091: PLDc_2" amino acids 134 to 251 (118 residues), 51.5 bits, see alignment E=1.4e-17 amino acids 327 to 444 (118 residues), 97.8 bits, see alignment E=7e-32 PF00614: PLDc" amino acids 220 to 245 (26 residues), 34.7 bits, see alignment (E = 1.9e-12) amino acids 398 to 424 (27 residues), 27.7 bits, see alignment (E = 3.1e-10)

Best Hits

Swiss-Prot: 53% identical to CLSA_YERPG: Cardiolipin synthase A (clsA) from Yersinia pestis bv. Antiqua (strain Angola)

KEGG orthology group: K06131, cardiolipin synthase [EC: 2.7.8.-] (inferred from 100% identity to vcm:VCM66_1610)

Predicted SEED Role

"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.8.-

Use Curated BLAST to search for 2.7.8.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (484 amino acids)

>CSW01_08395 cardiolipin synthase (Vibrio cholerae E7946 ATCC 55056)
MDKVYHFLTLLSIGIYWLLVAGVTIRVVLKRRAVSVSLAWLMVIYIIPFVGVLCYFLFGE
LNLGRKRAERAKEMFTPFGHWFRSLNDCQAHVQEGMGAHISRIDELCNNRMGIPALSGNT
LSLLNSPNEILHAIIDDIERAQFQIRMVFYIWHPGGLADAVASAVIQASKRGVNVKLLLD
SAGSPRFFRSPWEKMMRDAGIEVVQALEVSPWRIFLRRLDLRQHRKIIVIDDEIAYTGSM
NMVDPAYFKQNAGVGQWIDIMVRVTGPTVNVLSAIHCWDWEFETGSRMLPKNPECRLEPN
QPQHPIQVVPSGPGMPENLISQVLTLAINQANRSVCITTPYFVPSADLLATLKMTAQRGI
KVDIIIPKKNDSLMVQWASRAFYGELLEAGVQIHEFDGGLLHTKSVVIDQQFCLVGTVNL
DMRSLWLNFELTLAVDDLEFTQQMHWLQQQYIDQSHSVVYAEWEQRPWYNRFLERVFYLF
NPLL