Protein Info for CSW01_08065 in Vibrio cholerae E7946 ATCC 55056

Annotation: sensor histidine kinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 538 transmembrane" amino acids 12 to 35 (24 residues), see Phobius details amino acids 47 to 64 (18 residues), see Phobius details amino acids 171 to 193 (23 residues), see Phobius details PF17203: sCache_3_2" amino acids 39 to 168 (130 residues), 68.7 bits, see alignment E=1.5e-22 PF00989: PAS" amino acids 217 to 270 (54 residues), 27.4 bits, see alignment 7.2e-10 TIGR00229: PAS domain S-box protein" amino acids 221 to 269 (49 residues), 27.5 bits, see alignment 1.4e-10 PF13426: PAS_9" amino acids 225 to 307 (83 residues), 30.1 bits, see alignment E=1.2e-10 PF14501: HATPase_c_5" amino acids 420 to 533 (114 residues), 42.3 bits, see alignment E=1.6e-14 PF02518: HATPase_c" amino acids 422 to 536 (115 residues), 57.3 bits, see alignment E=5e-19

Best Hits

KEGG orthology group: K02476, two-component system, CitB family, sensor kinase [EC: 2.7.13.3] (inferred from 100% identity to vco:VC0395_A1210)

Predicted SEED Role

"Sensor kinase CitA, DpiB (EC 2.7.3.-)" in subsystem Orphan regulatory proteins (EC 2.7.3.-)

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3, 2.7.3.-

Use Curated BLAST to search for 2.7.13.3 or 2.7.3.-

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (538 amino acids)

>CSW01_08065 sensor histidine kinase (Vibrio cholerae E7946 ATCC 55056)
MVWSSITFRKRMLIIMTLSGLIELLLLVAAGFMYVKHSQEQEVGQKALGVAAFLAQTPAV
INMIKTGRASDDQQQSYRELTQLIGAAFIVIGDNQGIRLVHPIDERIGKPMVGGDNERAL
VEGEAYVSFAQGSLGKSVRGKAAVVDQHGQIIGVVSVGYLIERLQDRVEPFLFYLIATAL
LVVGANALVSSYASRRFQRAILGFEPEEIARLYVELDVTMSTLKEGIISIDDKGILRSIN
KSACEILGLRREQALNRRLTTILPESDLYTVLATGRTDHDIELYLNKHWIIANRSPIVVE
GKVVGAVSSFRLRDEINELTEQLAQTREYAEMLRSQTHEHRNKLNTISGLLQMGELDAVQ
QLIGQETEHYQVLIEFLRETIKDPLIAGMLLGKTERARELGLELMVEDGARLETLPIHIK
AEDVVTILGNLIDNAFEATLTAIRTLSPVPPERRVIEVSISDFGNEIILEVDDQGCGLPK
ELEHWQLTEKGVSSKAVQNRGVGLFLVKQLADRYQGQLDMHSKAQGTRMTVYLPKDEL