Protein Info for CSW01_07260 in Vibrio cholerae E7946 ATCC 55056

Annotation: type I secretion system permease/ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 720 transmembrane" amino acids 164 to 182 (19 residues), see Phobius details amino acids 194 to 215 (22 residues), see Phobius details amino acids 271 to 293 (23 residues), see Phobius details amino acids 299 to 319 (21 residues), see Phobius details amino acids 398 to 419 (22 residues), see Phobius details TIGR01846: type I secretion system ATPase" amino acids 38 to 711 (674 residues), 797.9 bits, see alignment E=3.9e-244 PF03412: Peptidase_C39" amino acids 42 to 142 (101 residues), 26.8 bits, see alignment E=6.2e-10 PF00664: ABC_membrane" amino acids 164 to 430 (267 residues), 165.8 bits, see alignment E=2.5e-52 PF00005: ABC_tran" amino acids 492 to 640 (149 residues), 125.9 bits, see alignment E=2.6e-40

Best Hits

KEGG orthology group: K12530, ATP-binding cassette, subfamily B, bacterial RtxB (inferred from 100% identity to vch:VC1448)

Predicted SEED Role

"RTX toxin transporter, ATP-binding protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (720 amino acids)

>CSW01_07260 type I secretion system permease/ATPase (Vibrio cholerae E7946 ATCC 55056)
MIGCRPFKNAVIHRRNNLMISNNERLTLICIHFYLSIISGNREKIKDESHLTDTENFKEE
LDKIQKEHKVKIRTKISQFKNIESLKTPAILFDQHDLPFITAKTNKDKCLIQRPNKETPE
VISSHELNSTWNKKSLVIQQAQSRFDITWFIPEFLQHKRVLSEILLFSFVLQILALISPL
FFQVVMDKVLVHQAWSTLDVLVFGLVITGVIEVVLRGLREYQYAHTANRIDIQLGLKLVQ
HLFGLPLMFFKSRQVGAIVTRVRELDTIREFLTGSMFTLTVELLFMFVFLYVMSLLSAPL
TGLFIATVPCYVLLAWWLTPRMQAAIEKQFSHAAANTSFLTETVAGSETLKSLAVEPRFI
RRWDEQTEKMVTTGYDVQQLNNRSNHLVQLLQKITSVAILWLGATEVLSLEMTIGQLIAF
NMMTNHIAQPLARMVELWGQFIQTRVAIEKLGDMLNLPVEQHTGSDNVTISGAISFKNIL
FRYQPDIPPTINDLSLDIRAGETLGVVGTSGSGKSTLARLLLRLYSPEQGSITIDGIPLN
HINVQQLRQRVGVVLQENFLFHKSVSENIAQSKPEASLEEIIEAAKLSGAHDFILKLPMG
YDTVLAEGGQSLSGGQRQRLAIARTLLSDPKVLILDEATSALDDESQAVIQANMASIARG
RTVITIAHRLSTVRDCDRIIVLHQGTIVEQGSHQQLLAYGKQYKQLWQLQQELKQEEASA