Protein Info for CSW01_07250 in Vibrio cholerae E7946 ATCC 55056

Annotation: type I secretion system permease/ATPase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 721 transmembrane" amino acids 170 to 188 (19 residues), see Phobius details amino acids 200 to 221 (22 residues), see Phobius details amino acids 277 to 300 (24 residues), see Phobius details amino acids 306 to 327 (22 residues), see Phobius details amino acids 388 to 410 (23 residues), see Phobius details TIGR01846: type I secretion system ATPase" amino acids 27 to 720 (694 residues), 1170.9 bits, see alignment E=0 PF03412: Peptidase_C39" amino acids 27 to 117 (91 residues), 22.6 bits, see alignment E=1.2e-08 PF00664: ABC_membrane" amino acids 171 to 437 (267 residues), 159.7 bits, see alignment E=1.9e-50 PF00005: ABC_tran" amino acids 499 to 648 (150 residues), 111.5 bits, see alignment E=7.4e-36

Best Hits

Swiss-Prot: 45% identical to LKTB_MANGL: Leukotoxin translocation ATP-binding protein LktB (lktB) from Mannheimia glucosida

KEGG orthology group: K12531, ATP-binding cassette, subfamily B, bacterial RtxE (inferred from 100% identity to vcm:VCM66_1402)

Predicted SEED Role

"RTX toxin transporter, ATP-binding protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (721 amino acids)

>CSW01_07250 type I secretion system permease/ATPase (Vibrio cholerae E7946 ATCC 55056)
MNTRFTTDAHRLAEQTLPQESPRTNWGIEAVVYAGQQFHKKSTSSQLKHALGVSYANLTD
MEMREAADYLGLKSQITKLSIQAFNTLPLPALIEYQGGWKVMIQTDDNGWTAYDPATDSL
HTLSFTSAESTAHYKVMLIADESLSVKEVKFGLSWFAPSILRQKSQLRDVFLYAIALQIF
ALVSPMLFENVIDKVLVGRSLSSLHVLALAMLALAIAEPAYSYLRNTVFGHLASQVNAEL
SGRLYRHLVGLPLTYFKQRQTGQIIARVREMAQIRQFLTGSTLMLLLDLIFVTVFLAVMF
HYASTLTWLVIGSLVIYFVLWLIAGPLIRKKVESEYESDANATTFLTEAVTGIETIKTTA
TEHRFLEQWQRILSQQLNRSFDAQKSGLIAGQAIALVQKLTAALLLWWGVSAVLKGEITP
GQLVAFNMLAGHVTQPVLRLAQIWQDFQHTLIALRRVGDILDEPRENSKQGLASVPELDG
GIEFSNIRFRYHQDAPEVLANLSLKIKPGQFIGVTGPSGSGKSTLTRLLQRLYVPQHGQV
LVDGMDLAIADPVSLRRNMSVVLQESILFSGSVADNIRLCKPQASDEEIRHAAQLAGALA
FIEGLPHGFNQPVGEKGAALSGGQRQRIALARALLVNPRILLLDEATSALDYNSEASIMS
NMDEICRGRTVISIAHRLNTIRHADNIFVLDKGQVAESGTHEELLAQQGLYAKLWTQQVG
E