Protein Info for CSW01_07065 in Vibrio cholerae E7946 ATCC 55056

Annotation: multidrug resistance protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 484 TIGR01845: efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family" amino acids 23 to 478 (456 residues), 577.8 bits, see alignment E=8.1e-178 PF02321: OEP" amino acids 77 to 267 (191 residues), 68.2 bits, see alignment E=4.2e-23 amino acids 300 to 476 (177 residues), 86.7 bits, see alignment E=9.3e-29

Best Hits

KEGG orthology group: None (inferred from 99% identity to vco:VC0395_A1020)

Predicted SEED Role

"Outer membrane component of tripartite multidrug resistance system" in subsystem Multidrug Resistance, Tripartite Systems Found in Gram Negative Bacteria

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (484 amino acids)

>CSW01_07065 multidrug resistance protein (Vibrio cholerae E7946 ATCC 55056)
MKNSVQTVGLLHKAAPYFTASLLSAFVLTGCSVPDHYPDLATMWEANELSSTNTFSHQAE
MDWPSANWWQRYQDAQLNHLIEEALQHSPSLEMAMARLKGAQGFARQAGAIRSFDLGLAA
SATESKVSERYQSATPPDGWNDYGTLTLNFQYDFDFWGKNRAAVVAATSELAAAEAESVA
ARLMISTSIANAYAELARLYANQETVHAALQVRNKTVELLEKRYANGLETLGSVSQAKAV
AASVEAELLGIQESIQLQKNALAALVGQGPDRAASIEEPHITLTSRYGLPSEAGVGLLGH
RADITAARWRAEAAAQQVGIAQAQFYPDVTLSAFIGYQAFGLDHLFDSGNDAGAIGPAIY
LPLFTGGRLEGQLTSAEARYQEAVAQYNGTLVQALYEVADVVTSSQALQARINKTEQAVQ
QAEQALHIATNRYQGGLATYLDVLVAEESLLNNQRALVNLQSRAFSLDLALIHALGGGFE
TTES