Protein Info for CSW01_06860 in Vibrio cholerae E7946 ATCC 55056

Annotation: siroheme synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 312 TIGR01470: siroheme synthase, N-terminal domain" amino acids 4 to 194 (191 residues), 197.9 bits, see alignment E=7.8e-63 PF13241: NAD_binding_7" amino acids 6 to 116 (111 residues), 115.2 bits, see alignment E=2.9e-37 PF10414: CysG_dimeriser" amino acids 152 to 206 (55 residues), 43.9 bits, see alignment E=2.4e-15

Best Hits

KEGG orthology group: K02304, precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase [EC: 1.3.1.76 4.99.1.4] (inferred from 100% identity to vcm:VCM66_1318)

Predicted SEED Role

"Siroheme synthase / Precorrin-2 oxidase (EC 1.3.1.76) / Sirohydrochlorin ferrochelatase (EC 4.99.1.4)" in subsystem Experimental tye or Heme and Siroheme Biosynthesis (EC 1.3.1.76, EC 4.99.1.4)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.3.1.76 or 4.99.1.4

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (312 amino acids)

>CSW01_06860 siroheme synthase (Vibrio cholerae E7946 ATCC 55056)
MRYFPLFLDLTNKPVLVVGGGEVACRKIDALLRADAKVTVISPQVAPALQAWIEQGKCHW
IQHFYSSHWLDKRYVQVWATTDNPELNHQVYKDAKEQGILVNVVDDQPYCDFITPSMIER
GRIQLAISSGGASPVLIRNIRETLEAVLAQNLALLADFGASKRNSIKDFLPSVDLRRQFW
ERFFAHPEVKNAQDRESLERIYIHLLTQSTDKVSATTWIEFGADVELLSLKALRYMQQAE
LVLHTQDCPFVFVDLCRRDAQRQSFNSSVELSTLLLQAQQETQNVCVLIPSGSSEYALLQ
GKATVLKMAQQG