Protein Info for CSW01_06855 in Vibrio cholerae E7946 ATCC 55056

Annotation: amino acid ABC transporter substrate-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 342 signal peptide" amino acids 1 to 26 (26 residues), see Phobius details PF00497: SBP_bac_3" amino acids 39 to 257 (219 residues), 103.3 bits, see alignment E=1.5e-33

Best Hits

Swiss-Prot: 62% identical to AAPJ_RHIL3: General L-amino acid-binding periplasmic protein AapJ (aapJ) from Rhizobium leguminosarum bv. viciae (strain 3841)

KEGG orthology group: K09969, general L-amino acid transport system substrate-binding protein (inferred from 100% identity to vcm:VCM66_1317)

Predicted SEED Role

"Glutamate Aspartate periplasmic binding protein precursor GltI (TC 3.A.1.3.4)" (TC 3.A.1.3.4)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (342 amino acids)

>CSW01_06855 amino acid ABC transporter substrate-binding protein (Vibrio cholerae E7946 ATCC 55056)
MANKLTVLASVVAASSAMLSLSASAAESTLDKVLSQGFITCGVSTGLPGFSNPNAKGEWE
GIDVEYCQAMAAAVLGDKTKVKFVPLTAKERFTALQSGEIDVLSRNTTWTLQRDSALGLN
FVGVNYYDGQGFMVKKDLGVKSAKELNGASVCVQSGTTTELNLADYFRNSGMTYKPVVFD
TAAQTSKGFDAGRCDVLTTDQSGLYALRLNLEKPDSAVVLPEIISKEPLGPVVRQDDDKW
FNVAKWVLYAMVNAEEYGITSKNVDEMMKSDNPEVKRILGLDGPKGTGLGIRDDWSYQIV
KQVGNYGESFDRTVGSGSPLKIDRGVNALWNAGGFMYAPPIR