Protein Info for CSW01_06800 in Vibrio cholerae E7946 ATCC 55056

Annotation: hybrid sensor histidine kinase/response regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1331 signal peptide" amino acids 1 to 28 (28 residues), see Phobius details transmembrane" amino acids 233 to 261 (29 residues), see Phobius details amino acids 395 to 412 (18 residues), see Phobius details TIGR00229: PAS domain S-box protein" amino acids 475 to 593 (119 residues), 50.1 bits, see alignment E=1.4e-17 PF00989: PAS" amino acids 475 to 583 (109 residues), 32.2 bits, see alignment E=3.8e-11 PF08448: PAS_4" amino acids 478 to 588 (111 residues), 43.7 bits, see alignment E=1.2e-14 PF13426: PAS_9" amino acids 483 to 585 (103 residues), 30.2 bits, see alignment 1.8e-10 PF00512: HisKA" amino acids 606 to 671 (66 residues), 78.1 bits, see alignment 1.7e-25 PF02518: HATPase_c" amino acids 718 to 829 (112 residues), 99.9 bits, see alignment E=4.9e-32 PF00072: Response_reg" amino acids 854 to 965 (112 residues), 68.4 bits, see alignment E=2.5e-22 amino acids 995 to 1105 (111 residues), 96.1 bits, see alignment E=5.8e-31 PF01627: Hpt" amino acids 1162 to 1243 (82 residues), 55.5 bits, see alignment 2.2e-18

Best Hits

KEGG orthology group: None (inferred from 100% identity to vcj:VCD_002990)

Predicted SEED Role

"FOG: CheY-like receiver"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (1331 amino acids)

>CSW01_06800 hybrid sensor histidine kinase/response regulator (Vibrio cholerae E7946 ATCC 55056)
MRSIKAMFVLLFCLMAILAVAMFKVTRQVADLRLESHQYSEQLFHFYRLSQELKQSSDHL
TKFARAYASTGNERWLRMFNQVLNVRNGKLPAPSNNDYEFWDVVVLNDSSELTPNANQRY
PTLIERIRQSGIGSVEFLELQNALALSDQLVALEREAFMAVKGWKREFAGEYRYTGEPDL
NFARSLLYSEKYFLEKAKIMAAIGSAHSNIVDRIESEVRAADEKAQFYERVNLVLVSLSL
LVIIASFILLWVIYIAPLSILLKTVVRQVRSEDYKFTLTQKAYGELQRFIDSLNVVFHHI
SEQLSFNTLVKDFNIIIRNHPTTEALCNQVTQFLLHHFPVELIGLYLYQNGVLTRIAGVG
QSESAQRDYSDPTTTHCSVLRSGKPYAMKSLNGNFQVVSTSGVIALNEVYYLPLQVNNQP
IALLELGTVGMLTMQQYHWLSQMLDDLSVAIQLSQNAEQQRLAERKVLEQSQLNQEILDA
TPNPMYCLSADGKFLTVNAKFLDLMGLYNNEVIDKEPQEIFPAEVAERFAAAHQVLTQQQ
SSQNYEVSLVDYTGVQREMLVYEASFSDRADKVNGIVGILLDMTERKEMEDELRKAKEAA
DAMSQAKGDFLANMSHEIRTPMNAILGMAHLALNTPLDTTQRKYVTRINESAKNLLGIIN
DILDFSKMEAGKLNVERIDFNLDDVLDNVTAVVSLKAQEKGIEFLMDIDPHIPLGLIGDP
LRLGQVMVNLCGNAVKFTSQGEIVLSARVSQLNEQQVTLRFAVKDTGIGIAQDKLDDLFD
AFSQADNSITRQYGGTGLGLSISKQLVELMGGQITVHSEEGKGSTFEFSVVCGLQDAKMR
DISQPVHGLADKRVLVVDDNDSARHILDSLLTAMRFNVVTVSNGFEALSEIQQKPFDMLF
VDWNMPGMNGIELLTRVKTLGLRGHMKSFLVTAYGREINLDGENSKLVDALIVKPVNPSN
LLDAIVTSYGIEHVRHKTNEAHHNSRPNFAGQSLLLVEDNEVNQEVALGLLQDTGLNVVV
ANHGQEALERLEHADFDLVLMDMQMPVMDGITATEHIRANPRWHSLPIVAMTANAMAIDI
ERCLQAGMNDHLSKPIEVDKFYQVLRHFLQVSDEQSFSSHSPNKPSASKPAMNALLDLPQ
LTGVDLEQAIFRIGGNQQRYFEILRHFIDSQVDELNSVTGLIEAQDWSSATRVAHTLKGS
AANLGLEALAQLAAEMEQSLEQQVLPSFELLQQAQSLLTQVDDELSAWEHQHKEPLLAEN
LDWGLWYQQLQQAINDYDVTALSLSKSIRQVSQWDSAQQAALISAIEDFDFEQAKALLAS
YPQLSGERLNQ