Protein Info for CSW01_05975 in Vibrio cholerae E7946 ATCC 55056

Annotation: cysteine/glutathione ABC transporter ATP-binding protein/permease CydC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 573 transmembrane" amino acids 15 to 35 (21 residues), see Phobius details amino acids 41 to 58 (18 residues), see Phobius details amino acids 138 to 159 (22 residues), see Phobius details amino acids 165 to 184 (20 residues), see Phobius details amino acids 246 to 267 (22 residues), see Phobius details amino acids 279 to 302 (24 residues), see Phobius details TIGR02868: thiol reductant ABC exporter, CydC subunit" amino acids 6 to 533 (528 residues), 459 bits, see alignment E=1.1e-141 PF00005: ABC_tran" amino acids 357 to 502 (146 residues), 111.9 bits, see alignment E=4e-36

Best Hits

Swiss-Prot: 50% identical to CYDC_ECOLI: ATP-binding/permease protein CydC (cydC) from Escherichia coli (strain K12)

KEGG orthology group: None (inferred from 100% identity to vcj:VCD_003163)

MetaCyc: 50% identical to glutathione/L-cysteine ABC exporter subunit CydC (Escherichia coli K-12 substr. MG1655)
7.4.2.-; 3.6.3.M9 [EC: 3.6.3.M9]

Predicted SEED Role

"Transport ATP-binding protein CydC" in subsystem Terminal cytochrome d ubiquinol oxidases or Terminal cytochrome oxidases

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.3.M9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (573 amino acids)

>CSW01_05975 cysteine/glutathione ABC transporter ATP-binding protein/permease CydC (Vibrio cholerae E7946 ATCC 55056)
MRDLLPYLKLYKKHWFGLTLGMLLALLTVLASIGLLTLSGWFLSAAAVAGLSIARETFNY
MLPGAFVRGFAMGRTAGRWGERVVTHNATFKLLTDLRVFFFEKLTPLIPGRLSAVRDADM
LNRIVADVDAMDHVYLRLINPVTVGVLGIAALTTLIAWFDPQLGMTLGAILLLVLLVWPT
LFYRLGKKNGQHLTQNKAELRVRTLDWLQGYSELTIFGAEQTYRQAILTAQDKLLRNQYV
NAQVSGLAQSLLLLANGWTLVLMIWLAADGVGGQTPDPLIALVAFATMASVELLMPIAGA
FQHLGQTLTSARRLNEIILAKPEVEFTAQPTAHNGQYNIEFNGVHFAYQANKPKAIDDFT
LTLAQGQKVAIVGQTGSGKSTLIQLLCRYWDVQQGQITIGGTDIREWRESDLRAAISVVS
QRVDILNGTLRDNLKLAKPDATDEALSDILQQVGLEKLLQDAALNTWLGEGGRQLSGGEK
RRLGIARALLHNAPILLLDEPTEGLDKQTEQQIMQLLHCHFGHKTVLFITHRLVNLEQMD
AIALIEQGQLVEYGHHHTLLAQHGRYHKLTQKL