Protein Info for CSW01_05875 in Vibrio cholerae E7946 ATCC 55056

Annotation: 3-phosphoserine/phosphohydroxythreonine transaminase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF00266: Aminotran_5
  • amino acids 23 to 367 (345 residues), 199.7 bits, E=3.7e-63
• TIGR01364: phosphoserine transaminase
  • amino acids 23 to 378 (356 residues), 531.8 bits, E=3.6e-164

Best Hits

Swiss-Prot: 100% identical to SERC_VIBCH: Phosphoserine aminotransferase (serC) from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)

KEGG orthology group: K00831, phosphoserine aminotransferase [EC: 2.6.1.52] (inferred from 100% identity to vco:VC0395_A0728)

MetaCyc: 67% identical to phosphoserine/phosphohydroxythreonine aminotransferase (Escherichia coli K-12 substr. MG1655)
Phosphoserine transaminase. [EC: 2.6.1.52]; 2.6.1.52 [EC: 2.6.1.52]; Succinyldiaminopimelate transaminase. [EC: 2.6.1.52, 2.6.1.17]

Predicted SEED Role

"Phosphoserine aminotransferase (EC 2.6.1.52)" in subsystem Glycine and Serine Utilization or Pyridoxin (Vitamin B6) Biosynthesis or Serine Biosynthesis (EC 2.6.1.52)

MetaCyc Pathways

• aspartate superpathway (23/25 steps found)
• superpathway of L-lysine, L-threonine and L-methionine biosynthesis I (17/18 steps found)
• L-lysine biosynthesis I (9/9 steps found)
• superpathway of sulfate assimilation and cysteine biosynthesis (9/9 steps found)
• pyridoxal 5'-phosphate biosynthesis I (7/7 steps found)
• superpathway of L-serine and glycine biosynthesis I (4/4 steps found)
• L-serine biosynthesis I (3/3 steps found)
• L-cysteine biosynthesis IX (Trichomonas vaginalis) (2/3 steps found)
• superpathway of pyridoxal 5'-phosphate biosynthesis and salvage (8/12 steps found)

KEGG Metabolic Maps

• Glycine, serine and threonine metabolism
• Lysine biosynthesis
• Vitamin B6 metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.17

Use Curated BLAST to search for 2.6.1.17 or 2.6.1.52

Protein Sequence (379 amino acids)

>CSW01_05875 3-phosphoserine/phosphohydroxythreonine transaminase (Vibrio cholerae E7946 ATCC 55056)
MVLITTLFVSRSNEHMEHNTDTVYNFSAGPAALPKAVMLQAQAEFVNWNHLGTSVMEISH
RSQPFIQVAEHAERDLRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDAETATYIDAGY
WAMSAVKEAKKYCTVDVFDAKIEKEGKIAVLPASEWRIANNAAYVHFCPNETIDGIEIND
LPVTDKPIVADMSSTILSREIDVSKYGVIYAGAQKNIGPAGICIAIVRDDLLDLASDLLP
GVLNYKILAEQESMFNTPPTFAWYLSGLVFQWLKAQGGVKAIEEVNRAKAALLYGYIDSS
DFYRNEIHPDNRSLMNVPFQLAKPELDDTFLELAEARGLVSLKGHRVVGGMRASIYNAMP
LEGVQALVDFMKEFEAQYA